Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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The effects Sunghyangjungkisan-ga-pogongng and herbs on Mouse neuroblastoma 2a cells damaged by hypoxia-reoxygenation

성향정기산가보공영(星香正氣散加補公英)과 단미(單味)들이 Hypoxia-reoxygenation에 의해 손상받은 Mouse Neuroblastoma 2a Cells에 미치는 영향(影響)

  • Yoo, Jin-Suk (Dept. of Neuropsychiatry, college of Oriental Medicine, Kyung Hee University) ;
  • Kim, Jong-Woo (Dept. of Neuropsychiatry, college of Oriental Medicine, Kyung Hee University) ;
  • Kang, Chul-Hun (Graduate School of East-West Medical Science) ;
  • Whang, Wei-Wan (Dept. of Neuropsychiatry, college of Oriental Medicine, Kyung Hee University)
  • 유진석 (경희대학교 한의과대학 신경정신의학교실) ;
  • 김종우 (경희대학교 한의과대학 신경정신의학교실) ;
  • 강철훈 (경희대학교 동서의학대학원) ;
  • 황의완 (경희대학교 한의과대학 신경정신의학교실)
  • Published : 2005.06.30
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Abstract

Object : This study was designed to asses the effect of Sunghyangjungkisan-ga-pogongng and herbs on Mouse neuroblastoma 2a cells damaged by hypoxia-reoxygenation. Method : Mouse neuroblastoma 2a (N2a) cells were measured by MTT assay and LDH assay after 48h hypoxia and 6h reoxygenation, Mouse neuroblastoma 2a (N2a) cells were treated by SHJG+P and herbs. Result : 1. SHJG+P was effective on LDH assay of hypoxia and reoxygenation. 2. The herbs were generally effective on LDH assay of hypoxia and reoxygenation. In MTT assay of hypoxia JP and GC were effecctive. In LDH assay of hypoxia all of herbs were effective. DMH, BC, SY, NS were more effective than other herbs. In LDH assay of reoxygenation KH, BH, BBR, DMH were especially effective. In MTT assay of reoxygenation most of herbs were not effective. But GC, SY, BH, JP were effective. Conclusion : The results imply that SHJG+P and all of berbs may have protective effect on dementia and GC, SY, BH, JP may have protective effect.

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