대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
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과루인약침(瓜蔞仁藥鍼)이 Ovalbumin-induced Asthma Mouse Model에 미치는 영향(影響)

The Effects of Trichosanthis Semen Herbal-acupuncture in ovalbumin-induced asthma mouse model

  • 김정현 (대전대학교부속한방병원 내과학교실) ;
  • 백경민 (대전대학교부속한방병원 내과학교실) ;
  • 이현의 (대전대학교부속한방병원 내과학교실) ;
  • 김종원 (대전대학교부속한방병원 내과학교실) ;
  • 오병열 (대전대학교부속한방병원 내과학교실) ;
  • 조현경 (대전대학교부속한방병원 내과학교실) ;
  • 유호룡 (대전대학교부속한방병원 내과학교실) ;
  • 김윤식 (대전대학교부속한방병원 내과학교실) ;
  • 설인찬 (대전대학교부속한방병원 내과학교실) ;
  • 심재철 (대전대학교부속한방병원 내과학교실)
  • Kim, Jung-Hyun (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
  • Baek, Kyung-Min (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
  • Lee, Hyun-Eui (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
  • Kim, Jong-Won (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
  • Oh, Byeong-Yeol (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
  • Jo, Hyun-Kyung (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
  • Yoo, Ho-Rhyong (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
  • Kim, Yoon-Sik (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
  • Seol, In-Chan (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
  • Shim, Jae-Chul (Department of Internal Medicine, College of Oriental Medicine, Daejeon University)
  • 발행 : 2005.09.30
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초록

Objectives : The aim of this study was to investigate the effect of Trichosanthis Semen Herbal-acupuncture(TS-HA) at Joksamni(ST36) on ovalbumin-induced asthma in mice. Methods : C57BL/6 mice were sensitized and challenged with ovalbumin(OVA) once a week for twelve weeks. The experimental group was treated with 1% concentrations of TS-HA at Joksamni(ST36) three times a week for the last eight weeks. Results : 1. The weight and total lung cells of the mice in the group treated with TS-HA decreased significantly compared with those of control group. 2. Total leukocytes and eosinophils in Bronchoalveoler-lavage fluid(BALF) of the mice in the group treated with TS-HA decreased significantly compared with those of control group. 3. Eosinophils in BALF of the mice in the group treated with TS-HA in photomicrographs decreased significantly compared with those of control group. 4. According to histological analysis of lung sections, adhension of collagen in TS-HA decreased significantly compared with that of control group. 5. The concentration of IgE, IL-4, IL-5 in BALF and IL-4, IL-5, IL-13 in serum of the mice in the group treated with TS-HA decreased significantly compared with that of control group. 6. The number of $Gr-^+/CD11b^+,\;CD11b^+,\;CD3e^-/CCR3^+,\;CD4^+,\;CD8^+\;CD3e^+/CD69^+,\;CD23^+/B220^+\;cells$ in the lungs of the mice in the group treated with TS-HA decreased significantly compared with those of control group. Conclusion : These results suggest that Trichosanthis Semen-herbal acupuncture at Joksamni(ST36) done on C57BL/6 mice is effective in part in relieving OVA-induced asthma in C57BL/6 mice.

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