The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Treatment Effect of Jecksodoodangkuisan against Colonic Mucosal Ulcer Induced by Indomethacin in Mouse

Indomethacin으로 유발된 생쥐의 대장점막 손상에 대한 적소두당귀산(赤小豆當歸散)의 치료효과

  • Hwang, Tae-Hyun (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • An, Joong-Hwan (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Lee, Seong-Hwan (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Lim, Seong-Woo (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Choi, En-Young (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University)
  • 황태현 (동국대학교 한의과대학 내과학교실) ;
  • 안중환 (동국대학교 한의과대학 내과학교실) ;
  • 이성환 (동국대학교 한의과대학 내과학교실) ;
  • 임성우 (동국대학교 한의과대학 내과학교실) ;
  • 최은영 (동국대학교 한의과대학 내과학교실)
  • Published : 2005.06.30
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Abstract

Objectives: This study was carried out to investigate the effects of Jecksodoodangkuisan(JD) and Jecksodoodangkuisankahyunjicho(JH) against Colonic Mucosal Ulcer induced by indomethacin in mouse. Methods: The normal group consisted of mice that were not inflammation-induced. The control group was untreated gastro-inflammation-elicited mice. The sample group mice were those administered BO, JD and JH after gastro-inflammation elicitation. Results: In the immunohistochemical change, the distribution of COX-1 in mice treated with BO, JD and JH noticeably increased than control group(P<0.05). The distributions of $NF-{\kappa}B$, p50, COX-2, ICAM-1, HSP70 and Substance P in mice treated with BO, JD and JH noticeably decreased more than control group(P<0.05). And JH was most effective treatment against Colonic Mucosal Ulcer in the immunohistochemical change. Conclusions: According to the above results, Jecksodoodangkuisan and Jeckmdoodangkuisankahyunjicho are applicable treatments for Colonic Mucosal Ulcer.

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