대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지

황기와 Chlorambucil 병용(倂用)이 P388D1 백혈병(白血病) 세포(細胞) 및 담암(擔癌)생쥐에 미치는 영향(影響)

Combined application of Astragali Radix and chlorambucil on anticancerous effect and host safety in Lukemia Cell(P388D1 cell) and its bearing mice

  • 전정회 (경희대학교 한의과대학 비계내과학교실) ;
  • 김진성 (경희대학교 한의과대학 비계내과학교실) ;
  • 윤상협 (경희대학교 한의과대학 비계내과학교실) ;
  • 류봉하 (경희대학교 한의과대학 비계내과학교실) ;
  • 류기원 (경희대학교 한의과대학 비계내과학교실)
  • Jeon, Jeong-Hoi (3rd Department of Internal Medicine, College of Oriental Medicine, Kyunghee University) ;
  • Kim, Jin-Sung (3rd Department of Internal Medicine, College of Oriental Medicine, Kyunghee University) ;
  • Yoon, Sang-Hyub (3rd Department of Internal Medicine, College of Oriental Medicine, Kyunghee University) ;
  • Ryu, Bong-Ha (3rd Department of Internal Medicine, College of Oriental Medicine, Kyunghee University) ;
  • Ryu, Ki-Won (3rd Department of Internal Medicine, College of Oriental Medicine, Kyunghee University)
  • 발행 : 2005.06.30
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초록

Objective : Anticancerous and host safety effects of the combination of Astragali Radix and chlorambucil are studied when it is applied to leukemia cell(P388D1 cell) related disease. Methods : After 5 groups of mice are treated by respective procedures (HG, CHL, HG+CHL, etc), the quantitative analyses (cell proliferation assay, mutagenesis test, survival rate, weight shift observation, tissue and blood analyses, etc) are conducted. Results : While sole injection of Astragali Radix extends the survival period and deter the liver and marrow function deterioration, combined injection (HG+CHL) shows more strong anticancerous effect than sole injection of Astragali Radix or Cholrambucil, and also does not cause any mutation on the normal cells and virulence on marrow and liver caused by leukemia. Conclusions : The combined application of Astragali Radix and chlorambucil has more effective anticancerous and host safety effects than independent use of them.

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