대한본초학회지 (The Korea Journal of Herbology)
- 제20권2호
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- Pages.91-102
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- 2005
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- 1229-1765(pISSN)
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- 2288-7199(eISSN)
좌금환(左金丸)과 수련환(茱連丸)이 고지혈증(高脂血症)에 미치는 영향
The Effects of Jwa Kum-Whan and Soo Ryeon-Whan on the Hyperlipidemia in Rats
- Kim, Yi-Heon (Dept. of Herbology, College of Oriental Medicine, Kyungwon University) ;
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Seong, Nak-Sul
(National Crop Experiment Station, RDA) ;
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Lee, Young-Jong
(Dept. of Herbology, College of Oriental Medicine, Kyungwon University)
- 발행 : 2005.06.30
초록
Objectives : By examining the effects of Jwa Kum-Whan composed of Coptidis Rhizoma and Evodiae Fructus by the ratio of 6:1 the effects of Soo Ryeon-Whan and composed of Coptidis Rhizoma and Evodiae Fructus by the ratio of 1:1 on hyperlipidemia, the present study attempted to reveal the change of effects based on the ratio of combination. Methods : Jwa Kum-Whan and Soo Ryeon-Whan were injected to rats suffered from induced hyperlipidemia, and then its influence on lipid. During the cultivation of hepatocytes, Jwa Kum-Whan and Soo Ryeon-Whan were added to culture media, and the expression of the enzymes relevant to fat metabolism of hepatocytes was examined. Results : 1. Jwa Kum-Whan significantly decreased total cholesterol(Tc), triglyceride(TG), and LDL-cholesterol(LDLc) of rats suffering from hyperlipidemia induced by high cholesterol diet. Soo Ryeon-Whan decreased LDLc, but had no significant on Tc and TG. 2. Jwa Kum-Whan increased the expression of cholesterol esterase, LDL-receptor, diacylglycerol acyltransferase (DGAT), acylCoA-cholesterol-acyltransferase (ACAT), peroxisome proliferator activated receptor gamma