동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)

  • 제19권3호
  • /
  • Pages.618-622
  • /
  • 2005
  • /
  • 1738-7698(pISSN)
  • /
  • 2288-2529(eISSN)
대한동의생리학회·한의병리학회 ( The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine)
권호 표지

흰쥐 퇴행성 관절염모델을 이용한 봉독약침의 치료효과

Effect of Bee Venom Herb-acupuncture on the Repair of Articular Full-thickness Defect in Rat

  • 조미애 (경희대학교 동서의학대학원 침구경락학교실) ;
  • 함대현 (경희대학교 동서의학대학원 침구경락학교실) ;
  • 이승기 (일침한의원) ;
  • 최선미 (한국한의학연구원 의료연구부) ;
  • 김건호 (경희대학교 동서의학대학원 침구경락학교실) ;
  • 심인섭 (가톨릭대학교 의과대학 퉁합의학교실) ;
  • 강성길 (경희대학교 한의과대학) ;
  • 이혜정 (경희대학교 동서의학대학원 침구경락학교실)
  • Zhao, Mei-Ai (Department of Oriental Medical Science, Graduate School of East-West Medial Science, Kyung-Hee University) ;
  • Hahm, Dae-Hyun (Department of Oriental Medical Science, Graduate School of East-West Medial Science, Kyung-Hee University) ;
  • Lee, Seung-Ki (Ilchim Oriental Hospital) ;
  • Choi, Sun-Mi (Department of Medical research, Korea Institute of Oriental Medicine) ;
  • Kim, Gun-Ho (Department of Oriental Medical Science, Graduate School of East-West Medial Science, Kyung-Hee University) ;
  • Shim, In-Sop (Department of Integrative Medicine, College of Medicine, The Catholic University of Korea) ;
  • Kang, Sung-Keel (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Kyung-Hee University) ;
  • Lee, Hye-Jung (Department of Oriental Medical Science, Graduate School of East-West Medial Science, Kyung-Hee University)
  • 발행 : 2005.06.25
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초록

Articular cartilage is an important target for studying the arthritic diseases. To verify the therapeutic effects of bee venom herb-acupuncture in vivo, 3${\mu}$l of diluted solution of bee venom for herb-acupuncture were injected into articular cavity once a day during 3 months after making full-thickness defects in rat articular cartilage. Histological examination and immunohistochemistry indicated that the chondrocyte-like tissue was formed during the repair process of cartilage injury, and the expression of a cartilage-specific protein, collagen type II, were significantly activated. It means that the expression of the gene encoding type I collagen was down-regulated, whereas those of collagen type II were up-regulated. Histological examination by hematoxylin-eosin staining indicated that the cells regained their original round morphology. In addition, a homogeneous distribution of articular cartilage extracellular matrices was detected around the cells. These results suggested that bee venom herb-acupuncture was very effective on the recovery of articular chondrocyte phenotype.

키워드

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