Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effect of Farfarae Flos Extract Drug on Immune Cells and Cytokines in BALF of OVA-induced Asthmatic Mice

관동화(款冬花)가 천식모델 생쥐의 BALF내 면역세포 및 사이토카인에 미치는 영향

  • Kwak, Sang-Kyo (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
  • Choi, Sun-Mi (Korea Institute of Oriental Medicine) ;
  • Park, Yang-Chun (Department of Internal Medicine, College of Oriental Medicine, Daejeon University)
  • 곽상교 (대전대학교 한의과대학 내과학교실) ;
  • 최선미 (한국한의학연구원) ;
  • 박양춘 (대전대학교 한의과대학 내과학교실)
  • Published : 2005.06.25
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Abstract

This experiment was designed to investigate the effect of Farfarae Flos(FF) on immune cells and cytokines in murine asthma model. C57BL/6 mice were sensitized and challenged with OVA(ovalbumin) for 9 weeks(3 times a week). The experimental group was treated with Farfarae Flos extract(FF) for the later 6 weeks(5 times a week). We measured IL-4, 1L-5, 1L-13, IgE, IFN-${\gamma}$ in bronchoalveolar lavage fluid of ovalbumin induced asthmatic mouse and observed murine lung tissue. The results were obtained as follows: Total leukocytes and eosinophils in BALF of the mice group treated with FF decreased significantly compared with those of control group. The concentration of IL-4, IL-5, IL-13, IgE in BALF of the mice group treated with FF decreased significantly compared with those of control group. The concentration of IFN-${\gamma}$ in BALF of the mice group treated with FF increased significantly compared with that of control group. According to the above results, it is suggested that FF extract might be useful applied for prevention and treatment of allergic asthma.

Keywords

References

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