Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Ginsenoside Contents and Hypocholesterolemic Effects of a By-Product in Ginseng Radix

인삼부산물 추출액의 ginsenosides 함량 및 고지방 식이에 있어 혈청 콜레스테롤 농도 개선에 미치는 효과

  • Sihn, Eon-Hwan (Department of Hotel Culinary Arts, Ulsan College) ;
  • Park, Sung-Jin (Department of Bio-food, Hallym College) ;
  • Han, Jong-Hyun (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Park, Sung-Hye (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 신언환 (울산과학대학 호텔조리과) ;
  • 박성진 (한림성심대학 바이오식품과) ;
  • 한종현 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 박성혜 (원광대학교 한의학전문대학원 한약자원개발학과)
  • Published : 2005.04.25
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Abstract

This study was conducted to investigate the application possibility of leaf and stem extract(LSE) extracted from mixture of leaf and stem of ginseng radix (Panax Ginseng C.A. Meyer). We conducted analysis of the ginsenoside content by HPLC. Also we investigate the effects of the LSE on the reduction of serum lipid and improvement of blood parameters in rats fed high fat diet 5 weeks. We examined by analyzing the serum total cholesterol, HDL-cholesterol, LDL-cholesterol, triglyceride and atherogenic index and hematological datas and serum metabolic variables. Sprague-Dawley rat weigh $150\;g\;{\pm}\;15\;g$, were ramdomly assigned to 4 groups, basal diet only(BDG), high fat diet weithout LSE(FDCG), high fat diet and 10% LSE(FD10G), high fat diet and 20% LSE(FD20G). The result of this study were as follow. Hematological datas of 4 groups were same level, which were not significant. The activities of ALP, GOT and LDH level were significantly different. Total cholesterol, LDL-cholesterol, triglyceride contentrations in serum and atherogenic index were remarkably reduced in LSE supplemented groups as compared high fat control groups. These result imply that LSE could be used as possible for decrease of serum lipid concentration.

Keywords

References

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