Journal of Photoscience
- Volume 12 Issue 3
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- Pages.113-117
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- 2005
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- 1225-8555(pISSN)
Investigation on the Interaction of Gabapentin with Bovine Serum Albumin by Spectroscopic Techniques
- Ashoka, S. (Department of Chemistry, Karnatak University) ;
- Seetharamappa, J. (Department of Chemistry, Karnatak University) ;
- Kandagal, P.B. (Department of Chemistry, Karnatak University) ;
- Shaikh, S.M.T. (Department of Chemistry, Karnatak University)
- Published : 2005.12.31
Abstract
Spectroscopic investigations on the interaction of gabapentin (GBP) with bovine serum albumin (BSA) were reported. The association constant of GBP-BSA system was determined at different temperatures (298, 302, 306 and 311 K) based on the fluorescence quenching results. The GBP was found to quench the fluorescence of BSA through static mechanism. Thermodynamic parameters, the standard enthalpy change,