Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Stereoselective Crossed-Aldol Condensation of Hetarylmethyl Ketones with Aromatic Aldehydes in Water : Synthesis of (2E)-3-Aryl-1-hetarylprop-2-en-1-ones

  • Basaif, Salem A. (Chemistry Department, Faculty of Science, King Abdulaziz University) ;
  • Sobahi, Tatiq R. (Chemistry Department, Faculty of Science, King Abdulaziz University) ;
  • Khalil, Ali Kh. (Chemistry Department, Faculty of Science, Ain Shams University) ;
  • Hassan, Mohamed A. (Chemistry Department, Faculty of Science, Ain Shams University)
  • Published : 2005.11.20
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Abstract

Aldol condensation of 2-acetylthiophene, 2-acetylpyrrole and 2-acetylpyridine with different aromatic aldehydes were carried out in water in heterogeneous phases in the presence of cetyltrimethylammonium bromide as cationic surfactant at room temperature. All the reactions occur in a short time with excellent yields of steroselective hetarylpropanones in water as environmental friendly solvent.

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References

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