Environmental Analysis Health and Toxicology

환경독성보건학회 (The Korean Society of Environmental Health and Toxicology)
권호 표지

한국인 본태성 고혈압군에서 에스트로젠 수용체-$\alpha$(유전자에 존재하는 다형성의 분포에 관한 연구

The Distributions of Three Genetic Polymorphisms in the Estrogen $Receptor-\alpha$ Gene in Korean Essential Hypertensives

  • 김지영 (삼육대학교 생명과학과) ;
  • 강병용 (삼육대학교 생명과학연구소) ;
  • 이강오 (삼육대학교 생명과학과)
  • Kim Ji Young (Dept. of Life Science, Sahmyook University) ;
  • Kang Byung Yong (Research Institute for Life Science, Sahmyook University) ;
  • Lee Kang Oh (Dept. of Life Science, Sahmyook University)
  • 발행 : 2005.09.01
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초록

Blood pressure, obesity and bone mineral density are multifactorial traits influenced by genetic factor. The purpose of this study was to clarify the association between three genetic polymorphisms in the estrogen receptor-$\alpha$ (ER -$\alpha$) gene and essential hypertension in korean population. One hundred and seventy-one people including 90 normotensives and 81 essential hypertentives were recruited. Among genetic polymorphisms studied, the Xba I RFLP in the intron 1 of this gene polymorphism was significantly associated with essential hypertension in women, suggesting the sexual dimorphism in genetic effect (P (<) 0.05). Further studied suggest that a larger sample size of this study are needed.

키워드

참고문헌

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