대한지역사회영양학회지 (Korean Journal of Community Nutrition)

대한지역사회영양학회 (The Korean Society of Community Nutrition)
권호 표지

아토피피부염에서 모유를 통한 식품 알레르겐에의 감작

Sensitization of Food Allergen in Breastfed Infant with Atopic Dermatitis

  • 한영신 (삼성서울병원 소아과 성균관대학교 의과대학) ;
  • 정상진 (삼성서울병원 소아과 성균관대학교 의과대학) ;
  • 안강모 (삼성서울병원 소아과 성균관대학교 의과대학) ;
  • 이광신 (삼성생명과학연구소) ;
  • 최혜미 (서울대학교 식품영양학과) ;
  • 이상일 (삼성서울병원 소아과 성균관대학교 의과대학)
  • Han Young Shin (Department of pediatrics, Samsung Medical Center Sungkyunkwan University School of Medicine) ;
  • Chunk Sang Jin (Department of pediatrics, Samsung Medical Center Sungkyunkwan University School of Medicine) ;
  • Ahn Kang Mo (Department of pediatrics, Samsung Medical Center Sungkyunkwan University Scho) ;
  • Shin Kwane (LeeSamsung Biomedical Research Institute) ;
  • Choi Hay Mie (Department of Food and Nutrition, Seoul National University) ;
  • Lee Sang Il (Department of pediatrics, Samsung Medical Center Sungkyunkwan University School of Medicine)
  • 발행 : 2005.06.01
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초록

Breastfeeding has been known as the best feeding practice to prevent allergies including atopic dermatitis (AD) However, the benefit on the prevention of allergic disease is still controversial. The objectives of this study were to examine the rate of sensitization to the protein of eggs, cow's milk and soy in exclusively breastfed infants and to evaluate antigen-antibody reaction between breast milk and serum of AD infant. Data on feeding and food hypersensitivity were obtained for 62 AD infants (32 male, 30 female) aged < 6 month who had visited Samsung Medical Center from September 2001 to May 2003. Food hypersensitivity was determined by measuring specific IgE to egg, cow's milk and soy. Specific IgE levels > 0.7 kU/L by CAP assay (Pharmacia, Uppsala, Sweden) were considered positive. The rates of sensitization in breastfed infants were $41.9\%$ (26/62) to egg, $30.6\%$ (19/62) to milk and $18.0\%$ (11/62) to soy. Immunoblotting analyses were performed using breast milk with the matched serum of seven AD infants (4 male/3 female). Binding patterns of AD infant's IgE to breast milk extract showed visible specific band for immunoglobulin, especially in case of a lactating mother who did not completely restricted ingestion of egg, milk and soy. These results indicate that sensitization to food allergen develops via breast milk feeding. Breast milk feeding should be recommended in infants at risk of developing allergic disease, but maternal intake of highly allergenic food might be restricted for prevention and treatment of food allergy among the babies with AD.

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