YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Antioxidant Activity of Vegetables or Fruits Extract in Mice

야채 및 과일추출물의 항산화작용

  • Heo Chan (College of Pharmacy, Kangwon National University) ;
  • Kim Nam Yee (College of Pharmacy, Kangwon National University) ;
  • Kim Hyun Pya (College of Pharmacy, Kangwon National University) ;
  • Heo Moon Young (College of Pharmacy, Kangwon National University)
  • 허찬 (강원대학교 약학대학) ;
  • 김남이 (강원대학교 약학대학) ;
  • 김현표 (강원대학교 약학대학) ;
  • 허문영 (강원대학교 약학대학)
  • Published : 2005.06.01
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Abstract

The ethanol extracts of the mixed vegetables (Bioactive Vegetables, BV) and the mixed fruits (Bioactive Fruits, BF) were evaluated for their in vivo antioxidant activities. Four weeks treatment of oral administration was performed to mice. A $KBrO_3$ as a potent oxidant was used to induce the oxidative stress for in vivo experiment. BV and BF were shown to possess the significant inhibitory effect of lipid peroxidation as measured by the level of malondialdehyde (MDA) formation although the potencies were not higher than those of well-known antioxidants such as vitamin C, trolox and quercetin. Furthermore, BV and BF inhibited DNA damage assessed by single cell gel electrophoresis (comet assay) and reduced the micronucleated reticulocyte (MNRET) formation of peripheral blood. Antioxidants tested also revealed potent inhibitory activities higher than BV and BF. These antigenotoxic activity profiles were similar to that of abovementioned inhibition of lipid peroxidation. Therefore, BV and BF having mild antioxidant activity as functional food candidates may be useful natural antioxidants by the inhibiting of lipid peroxidation and the protecting oxidative DNA and chromosomal damage.

Keywords

References

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