YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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HPLC Determination and Pharmacokinetic Profile of Procainamidein Korean Subjects

프로카인아미드의 HPLC 분석법 및 한국인에서의 약동학적 특성

  • Bae Jung-Woo (Lab. of Pharmacology, College of Pharmacy, Sungkyunkwan University) ;
  • Kim Hyun-Kyung (Lab. of Pharmacology, College of Pharmacy, Sungkyunkwan University) ;
  • Yang Sang-In (Lab. of Pharmacology, College of Pharmacy, Sungkyunkwan University) ;
  • Kim Ji-Hong (Lab. of Pharmacology, College of Pharmacy, Sungkyunkwan University) ;
  • Kim Kyung-Hye (Lab. of Pharmacology, College of Pharmacy, Sungkyunkwan University) ;
  • Jang Choon-Gon (Lab. of Pharmacology, College of Pharmacy, Sungkyunkwan University) ;
  • Park Young-Seo (Dept. Pediatrics, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Sohn Uy-Dong (College of Pharmacy, Chung-Ang University) ;
  • Lee Seok-Yong (Lab. of Pharmacology, College of Pharmacy, Sungkyunkwan University)
  • Published : 2005.06.01
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Abstract

Procainamide is the drug of second choice (after lidocaine) in most coronary care units for the treatment of sustained ventricular arrhythmias associated with acute myocardial infarction. The purpose of this study was to develop the efficient assay method of procainamide in human plasma and to assess the pharmacokinetic profile of procainamide in healthy Korean volunteers. The pharmacokinetics of procainamide administered orally was evaluated after a dose of 250 mg. Procainamide in plasma was assayed using a specific HPLC method with UV absorbance at 275 nm. AUC was $4.58{\pm}0.90 {\mu}g/ml-hr$, $C_{max}\;1.34{\pm}0.39{\mu}g/ml$, $T_{max}\;1.06{\pm}0.34 hr$ and half-life $3.07\pm0.34 hr$. $T_{max}$ was slightly shorter than that in Caucasian (1-2 hr), whereas the half-life was similar to that in Caucasian (2.5-4.1 hr).

Keywords

References

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