대한의생명과학회지 (Biomedical Science Letters)
- 제11권2호
- /
- Pages.201-209
- /
- 2005
- /
- 1738-3226(pISSN)
- /
- 2288-7415(eISSN)
Cerebroprotective Effect of Nociceptin on Transient Focal Cerebral Ischemia in Rats
- Lee Seung Yoon (Department of Neurosurgery, College of Medicine, Pusan National University) ;
- Lee Won Suk (Department of Pharmacology, College of Medicine, Pusan National University) ;
- Choi Chang Hwa (Department of Neurosurgery, College of Medicine, Pusan National University)
- 발행 : 2005.06.01
초록
This study aimed to investigate the cerebroprotective effect of nociceptin on transient focal cerebral ischemia in Sprague-Dawley rats by determining the changes in regional cerebral blood flow (rCBF) and the infarct size. Right middle cerebral artery (MCA) was occluded for 2 hours, and thereafter was followed by reperfusion by an intraluminal monofilament technique. An open cranial window was made on the right parietal bone for determination of continuous changes in rCBF by laser-Doppler flowmetry. The infarct size was morphometrically determined using the 2,3,5-triphenyltetrazolium chloride technique. In normal rats, nociceptin (