좌내흉동맥과 복재정맥편을 사용한 관상동맥우회로술 환자에서의 추적조사에서 MDCT의 유용성

Effectiveness of MDCT for the Followup of CABG Patients with LIMA to LAD and Saphenous Veins to Others

  • 강준규 (아주대학교 의과대학 흉부외과학교실) ;
  • 김형태 (아주대학교 의과대학 흉부외과학교실) ;
  • 박인덕 (아주대학교 의과대학 흉부외과학교실) ;
  • 정영미 (아주대학교 의과대학 흉부외과학교실) ;
  • 이철주 (아주대학교 의과대학 흉부외과학교실)
  • Kang Joon Kyu (Department of Thoracic and Cardiovascular Surgerym, Ajou University School of Medicine) ;
  • Kim Hyung Tai (Department of Thoracic and Cardiovascular Surgerym, Ajou University School of Medicine) ;
  • Park In Duk (Department of Thoracic and Cardiovascular Surgerym, Ajou University School of Medicine) ;
  • Chung Young Mi (Department of Thoracic and Cardiovascular Surgerym, Ajou University School of Medicine) ;
  • Lee Cheol Joo (Department of Thoracic and Cardiovascular Surgerym, Ajou University School of Medicine)
  • 발행 : 2005.06.01

초록

관상동맥우회로술 시에 이식편으로 사용되는 혈관들의 조합은 다양하다. 또한 수술 후의 장기 추적조사에 침습적인 관상동맥조영술을 이용하는데는 제한이 되어왔다. 본 연구에서는 좌내흉동맥을 좌전하행지에, 나머지의 목표혈관에는 복재정맥편을 사용하는 고전적인 방법으로 수술한 환자들에서 외래에서 비침습적인 MDCT로 이식편의 개존유무를 수술자의 입장에서 확인하는 방법의 유용성을 평가하고자 하였다. 대상 및 방법: 아주대학교의료원 흉부외과에서 1995년부터 2003년 사이에 다중관상동맥질환으로 관상동맥우회로술을 받았던 환자들 중 외래추적조사에서 특별한 증세의 재발을 호소하지 않았던 환자들을 대상으로 환자의 동의 하에 16 Channel MDCT를 시행하였던 80명의 환자들을 대상으로 이식도관의 개존성을 분석하였다. 결과: 대상환자 중 남녀비는 61:19였으며 평균연령은 $58.9\pm8.9$세였다. MDCT의 촬영시점은 최소 수술 후 7일에서 수술 후 9년으로 중앙값은 6.5년이었다. 환자당 평균 $3.10\pm1.9$개의 도관이 이식되었다. 좌전하행지에 좌내흉동맥을 72명의 환자에 이식하였고, 나머지의 목표혈관에는 복재정맥편을 이식하였다. 복재정맥편의 목표혈관은 좌전하행지 8예, 우관상동맥에 47예, 둔각지에 61예, 대각지에 60예를 각각 이식하였으며, 이중 42예에서 연속문합을 시행하였다. 이식편의 5년개존율이 좌내흉동맥이 $93.1\%$였고 복재정맥괸이 $89.3\%$였다 복재정맥편의 목표혈관별 5년개존율은 대각지 $94.9\%$, 둔각지$92.1\%$, 그리고 우관상동맥이 $79.2\%$순이었다. 복재정맥편의 경우 단독문합의 페쇄율이 $5\~21.3\%$로 연속문합의 $4.8\%$에 비해 높았다. 걸론: 관상동맥우회로 술 후에 외래추적기간 중 시행한 MDCT는 이식도관의 개존을 확인하는데 효과적이었으며, 향후 영상의 해상도가 높아지면 관상동맥의 질환을 진단하는데도 크게 기여할 것으로 기대된다. 본 조사의 결과에 의하면 관상동맥우회로술시에 좌내흉동맥과 복재정맥편을 혼용한 수술의 결과는 만족한 것으로 판단된다.

There are several options for choosing a graft in CABG, we routinely chose LIMA for LAD and great saphenous vein for other target vessels. To evaluate the posoperative graft patency, we have studied the results using a 16 slices multi-detector computed tomography. Material and Method: From 1995 to 2003, 80 CABG patients who did not complain any event of MACE have been examined by 16-MDCT, mostly in an out patient clinic. Result: There were 61 men and 19 women. MDCT was used as early as 7 days to 9 years post-operatively with a median follow-up period of 6.5 years, and mean follow-up peiod of $31.5\pm25.4$ months. Mean age was $58.4\pm12.6$ years old in men and $61.5\pm17.2$ years old in women. 72180 patients received LIMA to LAD, and all other patients received vein grafts for bypass. The target vessel of vein grafts were 8 in LAD, 47 in RCA, 60 in diagonals, and 61 in obtuse marginals. Among them 42 sequential anastomoses were performed. The mean graft number was $3.1\pm1.8$ grafts. 5 year graft patency rate of each grafts was as followings; $93.1\%$ in LIMA to LAD, $94.9\%$ in vein to diagonals, $92.1\%$ in vein to obtuse marginals, and $79.2\%$ in vein to RCA. Sequential grafting showed better graft patency than the isolated grafting $(95.2\%\;vs\;78.7\~95.0\%)$. Conclusion: In this study, CABG with LIMA and saphenous veins showed satisfactory longterm results. 16-MDCT provided good images for follow-up study after CABG. Additionally, as radiologic tools (64-MDCT, MRI) improve more in the future, they can be used for diagnosing preoperative anatomical coronary disease as well as cardiac functions.

키워드

참고문헌

  1. Sabiston DC Jr. Direct surgical management of congenital and acquired lesion ofthe coronary artery. Prog Cardiovasc Dis 1963;6:229
  2. Mack MJ, Brown PP, Kugelmass AD, et al. Current status and outcomes of coronary ravascularization 1999 to 2002:148,396 surgical and percutaneous procedures. Ann Thorac Surg 2004;77:761-8 https://doi.org/10.1016/j.athoracsur.2003.06.019
  3. Choi JB, Lee MK, Ryu DW, Choi SH. Determination of early graft patency using CT angiography after coronary artery bypass surgery. Korean J Thorac Cardiovasc Surg 2004;37:570-7
  4. Ko YG, Choi DH, Jang YS, et al. Assesment of coronary artery bypass graft patency by multislice computed tomography. Yonsei Med J 2003;44:438-44
  5. Song MH, Ito T, Watanabe T, Nakamura H. Multidetector computed tomography versus coronary angiohraphy in evaluation of coronary artery bypass grafts. Ann Thorac Surg 2005;79:585-8 https://doi.org/10.1016/j.athoracsur.2004.08.014
  6. Kuettner A, Beck T, Drosch T, et al. Diagnostic accuracy of nonimvasive coronary imaging using multidetector slice spiral computed tomography with 188 ms resolution. J Am Coll Cardiol 2005;45:123-7 https://doi.org/10.1016/j.jacc.2004.10.050
  7. Shim SS, Kim Y, Lim SM. Improvement of image quality with {beta}-blocker premedication in ECG-Gated 16-MDCT coronary angiography. Am J Roentgenol 2005;184:649-54 https://doi.org/10.2214/ajr.184.2.01840649
  8. Dirksen MS, Jukema JW, Bax JJ, et al. Cardiac multidetector-row computed tomography in patients with unstable angina. Am J Cardiol 2005;95:457-61 https://doi.org/10.1016/j.amjcard.2004.10.010
  9. Herzog C, Wimmer-Greinecker G, Schwarz W, et al. Progress in CT imaging for the cardiac surgeon. Semin Torac Vardiovasc Surg 2004;16:242-8 https://doi.org/10.1053/j.semtcvs.2004.08.015
  10. Burgstahler C, Kuettner A, Kopp AF, et al. Non-invasive evaluation of coronary artery bypass grafts using multi-slice computed tomography: Initial clinical experience. Int J Cardiol 2003;90:275-80 https://doi.org/10.1016/S0167-5273(02)00569-7
  11. Dion R. Complete arterial revascularization with the internal thoracic arteries. Oper Tech Card Thorac Surg 1996;1:84-107 https://doi.org/10.1016/S1085-5637(07)70049-9
  12. Son JH, Lee WY, Kim EJ, et al. Middle and long term results of 34 cases of emergency coronary artery bypass graft surgery. Korean J Thorac Cardiovasc Surg 2003;36:741-7
  13. Choi JB, Park KJ, Yang HW, Lee SY, Choi SH. Vein injury and wound complications associated with techniques of saphenous vein harvest. Korean J Thorac Cardiovasc Surg 2003;36:504-9
  14. O'Neill MJ Jr, Wolf PD, O'Neill TK, Montesano RM, Waldausen JA. A rationale for the use of sequential coronary artey bypass grafts. J Thorac Cardiovasc Surg 1981;81:686-90