Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Sesquiterpenes from Syneilesis palmata and Their Cytotoxicity Against Human Cancer Cell Lines In Vitro

  • Lee Kyu Ha (Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University) ;
  • Cho Sang Un (Research Institute of Chemical Technology) ;
  • Lee Kang Ro (Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University)
  • Published : 2005.03.01
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Abstract

The chromatographic separation of the MeOH extract from the aerial parts of Syneilesis palmata led to the isolation of a new sesquiterpene glycoside 4, together with four known compounds. Their structures were characterized to be 4$\beta$,5$\beta$-epoxy-caryophill-8,(15)-ene (1), 3$\beta$­hydroxy-gultin-5-ene (2), 4$\alpha$,5$\beta$-dihydroxy-caryophill-8,(15)-ene (3), (-)-oplopan-4-one-10-$\alpha$-O­$\beta$-D-glucose (4) and 3-hexenyl-1-O-$\beta$-D-glucopyranose (5), based on spectroscopic and chemical methods. Compound 2 showed moderate cytotoxicity against five human tumor cell lines in vitro with its EDso values ranging from 5.90-1 0.83 $\mu$g/mL.

Keywords

References

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