성인 재발성 폐렴에 대한 임상적 고찰 - 한림대학교 의료원 내원 환자를 대상으로 -

Clinical Investigation of Recurrent Pneumonia in Adults - Analysis of Patients From Hallym University Medical Center -

  • 엄광석 (한림대학교 의과대학 내과학교실) ;
  • 전강 (한림대학교 의과대학 내과학교실) ;
  • 신태림 (한림대학교 의과대학 내과학교실) ;
  • 장승훈 (한림대학교 의과대학 내과학교실) ;
  • 반준우 (한림대학교 의과대학 내과학교실) ;
  • 이재영 (한림대학교 의과대학 내과학교실) ;
  • 박용범 (한림대학교 의과대학 내과학교실) ;
  • 김철홍 (한림대학교 의과대학 내과학교실) ;
  • 전만조 (한림대학교 의과대학 내과학교실) ;
  • 박상면 (한림대학교 의과대학 내과학교실) ;
  • 김동규 (한림대학교 의과대학 내과학교실) ;
  • 이명구 (한림대학교 의과대학 내과학교실) ;
  • 현인규 (한림대학교 의과대학 내과학교실) ;
  • 정기석 (한림대학교 의과대학 내과학교실)
  • Eom, Kwang-Seok (Department of Internal Medicine, College of Medicine, Hallym University) ;
  • Jeon, Gang (Department of Internal Medicine, College of Medicine, Hallym University) ;
  • Shin, Taerim (Department of Internal Medicine, College of Medicine, Hallym University) ;
  • Jang, Seung Hun (Department of Internal Medicine, College of Medicine, Hallym University) ;
  • Bahn, Joon-Woo (Department of Internal Medicine, College of Medicine, Hallym University) ;
  • Lee, Jae Young (Department of Internal Medicine, College of Medicine, Hallym University) ;
  • Park, Yong Bum (Department of Internal Medicine, College of Medicine, Hallym University) ;
  • Kim, Cheol Hong (Department of Internal Medicine, College of Medicine, Hallym University) ;
  • Jeon, Man-Jo (Department of Internal Medicine, College of Medicine, Hallym University) ;
  • Park, Sang Myeon (Department of Internal Medicine, College of Medicine, Hallym University) ;
  • Kim, Dong Gyu (Department of Internal Medicine, College of Medicine, Hallym University) ;
  • Lee, Myung Goo (Department of Internal Medicine, College of Medicine, Hallym University) ;
  • Hyun, In-Gyu (Department of Internal Medicine, College of Medicine, Hallym University) ;
  • Jung, Ki-Suck (Department of Internal Medicine, College of Medicine, Hallym University)
  • 투고 : 2004.06.15
  • 심사 : 2004.07.15
  • 발행 : 2004.07.30

초록

연구배경 : 재발성 폐렴은 첫 번째 폐렴에서 완전히 회복한 후 다시 발생하는 폐렴으로 여러 가지 질환이 동반되어있는 경우가 많다. 성인에서도 드물지 않게 나타나지만 세계적으로도 연구 결과가 많지 않고 국내 연구 보고는 전무하다. 이에 저자들은 국내의 성인 환자에서 발생하는 재발성 폐렴의 임상 양상, 동반질환 등에 대해 연구하였다. 방 법 : 5년 5개월 동안 한림대학교 의료원 5개 병원에서 폐렴을 진단받고 치료받은 5513명의 의무기록을 검토하여 재발성 폐렴의 정의에 합당한 58명을 대상으로 후향적으로 연구를 시행하였다. 결 과 : 5년 5개월(65개월) 동안 재발성 폐렴 환자는 58명(1.05%, 58/5513)이었다. 남자가 37명이었고 여자가 21명이였으며 평균 나이는 66.4(${\pm}14.9$)세였다. 각 폐렴의 에피소드 사이의 시간 간격은 평균 18.4개월이었다. 재발성 폐렴에 동반된 질환으로는 호흡기 질환(25예), 심장 질환(13예), 당뇨병(13예), 폐암(7예), 폐암을 제외한 악성 질환(11예), 신경학적 질환(7예), 기타 질환(8예) 등이 동반되었으며 세 명의 환자에서는 동반질환 없이 재발성 폐렴이 나타났다. 2번 이상 재발성 폐렴을 경험한 8명의 환자에서는 호흡기 질환, 신경학적 질환에 의한 흡인, 심장 질환이 동반되었으며 한 명은 동반질환 없이 2차례의 재발성 폐렴이 발생하였다. 전체 재발성 폐렴 67건 중에서 폐의 같은 위치에 재발성 폐렴이 발생한 경우는 30건(47.8%, 30/67)이었고 호흡기 질환과 폐암이 가장 흔하게 동반되어 있었다. 재발성 폐렴의 원인균으로는 Streptococcus pneumoniae, methicillin-resistant Staphylococcus aureus, P. aeru-ginosa, K. pneumoniae, 비정형균 등이 동정되었다. 결 론 : 재발성 폐렴은 성인에서는 비교적 흔하지 않은 질환으로 알려져 있지만 실제로 적지 않은 발생 빈도를 가지고 있고 대부분 원인질환을 동반하고 있는 것으로 나타난다. 폐암을 포함한 호흡기 질환이 가장 흔한 동반질환이며 그 외에 여러 질환이 재발성 폐렴과 동반된다. 따라서 재발성 폐렴 환자의 치료 시에는 동반질환을 찾으려고 하는 노력과 그에 대한 적절한 치료도 필요할 것으로 생각된다.

Background : Recurrent pneumonia in adults is not uncommon. However, there is no domestic data about recurrent pneumonia in adults. Therefore, we investigated the associated diseases and clinical findings of recurrent pneumonia in adults. Methods : Among 5513 patients who were treated in five teaching hospitals of Hallym medical center?over a 5-year period, we retrospectively reviewed the medical records of the 58 who were compatible with diagnostic criteria of recurrent pneumonia. Results : The number of patients with recurrent pneumonia was 58 (1.05%, 58/5513) during the 5 years. Thirtyseven patients were male and 21 were female. Mean age was 66.4 (${\pm}14.9$) years. Median interval between each pneumonic episode was 18.5 months. Associated diseases were 25 cases of respiratory diseases, 13 of heart diseases, 13 of diabetes mellitus, 7 of lung malignancies, 11 of malignancies other than lung, 7 of neurologic disease, and 8 of miscellaneous diseases. Three cases had no underlying illness. Of the 8 cases with 2 or more times of recurrence, 4 were associated with respiratory diseases, 2 with aspiration pneumonia due to neurologic diseases, 1 with heart disease and 1 with no underlying illness. Recurrent pneumonic episodes affecting the same location were 30 of the total recurrent pneumonic episodes (30/67, 47.8%) and common associated diseases were respiratory diseases including lung malignancies. The etiology of recurrent pneumonia was Streptococcus pneumoniae, methicillinresistant Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, atypical organisms, etc. Conclusion : Recurrent pneumonia in adults had a low incidence rate compared with children, but most cases had associated illness. Respiratory diseases including lung cancer were the most common associated illness of recurrent pneumonia.

키워드

참고문헌

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