대한두경부종양학회지 (Korean Journal of Head & Neck Oncology)

  • 제20권2호
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  • Pages.147-155
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  • 2004
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  • 1229-5183(pISSN)
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  • 2586-2553(eISSN)
대한두경부종양학회 (The Korean Society for Head and Neck Oncology)
권호 표지

두경부 편평상피세포암에서 종양억제유전자들의 변이

Alteration of Multiple Tumor Suppressor Genes in Head and Neck Squamous Cell Carcinoma

  • 송시연 (영남대학교 의과대학 이비인후과학교실) ;
  • 박강식 (영남대학교 의과대학 이비인후과학교실) ;
  • 배창훈 (영남대학교 의과대학 이비인후과학교실)
  • Song Si-Youn (Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine Yeungnam University) ;
  • Park Kang-Shik (Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine Yeungnam University) ;
  • Bai Chang-Hoon (Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine Yeungnam University)
  • 발행 : 2004.11.01
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초록

Objectives: Head and neck squamous cell carcinoma (HNSCC) is the most common head and neck malignant tumor. The molecular genetic changes involving both oncogenes and tumor suppressor genes are known to be involved in head and neck squamous cell carcinogenesis, but the roles of the known tumor suppressor genes in carcinogenesis are not fully elucidated. The objectives of this study are to demonstrate the genetic alterations including the loss of heterozygosity (LOH) , amplification, and microsatellite instability of known tumor suppressor genes in HNSCC and to evaluate the relationship between genetic alterations of tumor suppressor genes and clinicopathologic features. Materials and Methods: Genetic alterations of 10 micro satellite markers of the 6 known tumor suppressor genes (APC, EXT1, DPC4, p16, FHIT, and PTEN) were analysed by DNA-PCR in paraffin-embedded histologically confirmed HNSCC specimens. Results: The genetic alterations of tumor suppressor genes were found frequently. Among the genetic alterations, LOH was most frequently found one. LOH was found frequently in APC (45.4%), EXT1 (36.4%), DPC4 (54.5%), and p16 (50%), but not found in FHIT. Also, the author found that abnormalities of APC gene was related to cervical lymph node metastasis and recurrence and that abnormalities of EXT1 gene were coexisted with those of APC gene or DPC4 gene. But these coexistences had no correlation with clinical features. Conclusion: These results suggested that APC, EXT1, p16, and DPC4 genes might play important roles and multiple tumor suppressor genes may participate dependently or independently in the carcinogenesis of HNSCC. These results also suggested that APC gene might relate to prognosis.

키워드

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