Tuberculosis and Respiratory Diseases

  • 제56권3호
  • /
  • Pages.315-320
  • /
  • 2004
  • /
  • 1738-3536(pISSN)
  • /
  • 2005-6184(eISSN)
대한결핵및호흡기학회 (The Korean Academy of Tuberculosis and Respiratory Diseases)
권호 표지

Gemcitabine에 의한 약물 유발성 간질성 폐렴 1예

A Case of Drug Induced Interstitial Pneumonitis by Gemcitabine

  • 이성순 (인제대학교 의과대학 내과학교실) ;
  • 함초롬 (인제대학교 의과대학 내과학교실) ;
  • 진재용 (인제대학교 의과대학 내과학교실) ;
  • 이혜란 (인제대학교 의과대학 내과학교실) ;
  • 김수영 (인제대학교 의과대학 방사선과학교실) ;
  • 김미영 (인제대학교 의과대학 방사선과학교실) ;
  • 이현경 (인제대학교 의과대학 내과학교실) ;
  • 이혁표 (인제대학교 의과대학 내과학교실) ;
  • 염호기 (인제대학교 의과대학 내과학교실) ;
  • 최수전 (인제대학교 의과대학 내과학교실)
  • Lee, Sung Soon (Department of Internal Medicine, Inje University, Medical School) ;
  • Ham, Cho Rom (Department of Internal Medicine, Inje University, Medical School) ;
  • Chin, Jae-Yong (Department of Internal Medicine, Inje University, Medical School) ;
  • Lee, Hye Ran (Department of Internal Medicine, Inje University, Medical School) ;
  • Kim, Su Young (Department of Radiology, Inje University, Medical School) ;
  • Kim, Mi-young (Department of Radiology, Inje University, Medical School) ;
  • Lee, Hyun-Kyung (Department of Internal Medicine, Inje University, Medical School) ;
  • Lee, Hyuk Pyo (Department of Internal Medicine, Inje University, Medical School) ;
  • Yum, Ho-Kee (Department of Internal Medicine, Inje University, Medical School) ;
  • Choi, Soo Jeon (Department of Internal Medicine, Inje University, Medical School)
  • 발행 : 2004.03.30
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초록

Gemcitabine은 최근 사용이 증가되고 있는 항암제로서 호흡기 부작용이 흔히 발생하나 대부분 일시적이고 자연 관해된다. 하지만 드물게 gemcitabine에 의한 심각한 폐 독성이 발생할 수 있으며, 이는 조기 진단 및 치료가 중요하다. 저자들은 gemcitabine 치료 후 발생한 중증 약물 유발성 간질성 폐렴 환자에서 스테로이드 치료 후 호전된 증례를 경험하였기에 보고하는 바이다.

Gemcitabine is an effective newly developed chemotherapeutic agent, which is increasingly being used to treat non-small cell lung, ovarian and breast cancers. Pulmonary toxicity is usually self-limiting mild dyspnea, bronchospasm, but severe pulmonary toxicity is rarely reported. Herein, we report drug induced interstitial lung disease associated with gemcitabine treatment. High resolution computerized tomogram (HRCT) showed an increased ground glass opacity and thickened septal lines. The patient showed a rapid good response with prednisolone treatment.

키워드

참고문헌

  1. Kaye SB. Gemcitabine: current status of phase I and II trials. J Clin Oncol 1994;12:1527-31
  2. Anderson H, Lund B, Bach F, Thatcher N, Walling J, Hansen HH. Single agent activity of weekly gemcitabine in advanced nonsmall cell lung cancer: a phase II study. J Clin Oncol 1994;12:1821-6
  3. Carmichael J, Possinger K, Phillip P, Bey kirch M, Kerr H, Walling J, et al. Advanced breast cancer: a phase II trial with gemcita bine. J Clin Oncol 1995;13:2731-6
  4. Nelson R, Tarassoff P. Dyspnoea with ge mcitabine is commonly seen, often disease related, transient and rarely severe. Eur J Cancer 1995;31(A) (Suppl 5):S197-8
  5. Pavlakis N, Bell DR, Millward MJ, Levi JA. Fatal pulmonary toxicity resulting from tre atment with gemcitabine. Cancer 1997;80:286-91
  6. Vander Els NJ, Miller V. Successful tre atment of gemcitabine toxicity with a briefcourse of oral corticosteroid therapy. Chest 1998;114:1779-81
  7. Marruchella A, Fiorenzano G, Merizzi A, Rossi S, Chiodera PL. Diffuse alveolar damage in a patient treated with gemcitabine. Eur Respir J 1998;11:504-6
  8. Rosado MF, Kett DH, Schein RMH, Baraona FJ, Sridhar KS. Severe pulmonary toxicity in a patient treated with gemcitabine. Am J Clin Oncol 2002;25:31-3
  9. Boicelle PM, Morrin MM, Huberman MS. Gemcitabine pulmonary toxicity : CT features. J Comput Assit Tomogr 2000;24:977-80
  10. Anderson BS, Luna MA, Mario A, Yee C, Hui KH, Keating MJ, et al. Fatal pulmonary failure complicating high-dose cytosine arabi noside therapy in acute leukemia. Cancer 1990;65:1079-84
  11. Anderson BS, Cogan BM, Keating MJ, Estey EH, McCreadie KB, Freireich EJ. Subacute pulmonary failure complicating therapy with high dose ara-C in acute leukemia. Cancer 1985;56:2181-4
  12. Foucher P, Biour M, Blayac JP, Godard P, Sgro C, Kuhn M, et al. Drugs that mayinjure the respiratory system. Eur Respir J 1997;10: 265-279
  13. Haupt HM, Hutchins GM, Moore GW. Ara-C Lung: noncardiogenic pulmonary edema com plicating cytosine arabinoside therapy of leukemia. Am J Med 1981;70:256-61