참고문헌
- Brauch H, Johnson B, Hovis J, Yano T,Gazdar A, Pettengill OS, Graziano S, Sore-nson GD, Poiesz BJ, Minna J, Linehan N, Zbar B. Molecular analysis of the short arm of chromosome 3 in small-cell and nonsmall-cell carcinoma of the lung. N Engl J Med 1987;317:1109-13
- Naylor SL, Johnson BE, Minna JD, Saka-guchi AY. Loss of heterozygosity of chro-mosome 3p markers in small-cell lung cancer. Nature(London) 1987;329:451-4
- Yokota J, Wada M, Shimosato Y, Terada M, Sugimura T. Loss of heterozygosity on chro-mosome 3, 13, 17 in small cell carcinoma and on chromosome 3 in adenocarcinoma of the lung. Proc Natl Acad Sci USA 1987;84:9252-6
- Hibi K, Takahashi T, Yamakawa K, Ueda R, Sekido Y, Ariyoshi Y, Suyama M, Takagi H, Nakamura Y, Takahashi T. Three distinct regions involved in 3p deletions in human lung cancer. Oncogene 1992;7:445-9
- Sundaresan V, Ganly P, Hasleton P, Rudd R, Sinha G, Bleehen NM, Rabbitts P. p53 and chromosome 3 abnormalities, characteristic of malignant lung tumors, are detectable in preinvasive lesions of the bronchus. Onco-gene 1992;7:1989-97
- Hung J, Kishimoto Y, Sugio K, Virmani A, McIntire DD, Minna JD, Gazdar AF. Allele-specific chromosome 3p deletions occur at an early stage in the pathogenesis of lung carcinoma. J Am Med Assoc 1995;273:558-63
- Killary AM, Wolf ME, Giambernardi TA, Naylor SL. Definition of a tumor suppressor locus within human chromosome 3p21-p22. Proc Natl Acad Sci USA 1992;89:10877-81
- Daly MC, Xiang RH, Buchhagen D, Hensel CH, Garcia DK, Killary AM, Minna JD, Naylor SL. A homozygous deletion on chro-mosome 3 in a small cell lung cancer cell line correlates with a region of tumor sup-pressor activity. Oncogene 1993;8:1721-9
- Kok K, Hosfra R, Pilz A, van den Berg A, Terpstra P, Buys CH, Carrit B. A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin activation enzyme. Proc Natl Acad Sci USA 1993;90:6071-5
- Sekido Y, Bader S, Latif F, Gnarra JR, Gadzar AF, Linehan M, Zbar B, Lerman MI, Minna JD. Molecular analysis of the von Hippel-Lindau disease tumor suppressor gene in human lung cancer cell lines. Oncogene 1994;9:1599-604
- Ohta M, Inoue H, Cotticelli MG, Kastury K, Baffa R, Palazzo J, Siprashvili Z, Mori M, McCue P, Druck T, Croce CM, Heubner K. The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associatedt(3;8)breakpoint, is abnormal in digestive tract cancers. Cell 1996;84:587-97
- Kastury K, Baffa R, Druck T, Ohta M, Cotticelli MG, Inoue H, Negrini M, Rugge M, Huang D, Croce CM, Palazzo J, Huebner K. Potential gastrointestinal tumor suppressor locus at the 3p14.2 FRA3B site identified by homozygous deletions in tumor cell lines. Cancer Res 1996;56:978-83
- Sozzi G, Alder H, Tornielli S, Corletto V, Baffa R, Veronese ML, Negrini M, Pilotti S, Pierotti MA, Huebner K, Croce CM. Aber-rant FHIT transcripts in Merkel cell car-cinoma. Cancer Res 1996;56:2472-4
- Negrini M, Monaco C, Vorechovsky I, Ohta M, Druck T, Baffa R, Huebner K, Croce CM. The FHIT gene at 3p14.2 is abnormal in breast carcinomas. Cancer Res 1996;56:3173-9
- Virgilio L, Shuster M, Gollin SM, Veronese ML, Ohta M, Huebner K, Croce CM. FHIT gene alterations in head and neck squamous cell carcinomas. Proc Natl Acad Sci USA 1996;93:9770-5
- Smeets DF, Scheres JM, Hustinx TW. The most common fragile site in man is 3p14. Hum Genet 1986;72:215-20
-
Huang Y, Garrison PN, Barnes LD. Cloning of the Schizosaccharomyces pombe gene encoding diadenosine
$5'5'''-P^1,P^4$ -tetrapho-sphate$(A_{P4}A)$ asymmetrical hydrolase: seque-nce similarity with histidine triad (HIT) family. Biochem J 1995;312:925-32 - Barnes LD, Garrison PN, Siprashvili Z, Gura-nowski A, Robinson AK, Ingram SW, Croce CM, Otha M, Huebner K. Fhit, a putative tumor suppressor in humans, is a dinu-cleoside 5', 5'''-P1,P3 triphosphate hydrolase. Biochemistry 1996;35:11529-35
- Sozzi G, Veronese ML, Negrini M, Baffa R, Cotticelli MG, Inoue H, Tornielli S, Pilotti S, Gregorio LD, Pastorino U, Pierotti MA, Ohta M, Heubner K, Croce CM. The FHIT gene at 3p14.2 is abnormal in lung cancer. Cell 1996;85:17-26
- Yanagisawa K, Kondo M, Osada H, Uchida K, Takagi K, Masuda A, Takahashi T, Taka-hashi T. Molecular analysis of the FHIT gene at 3p14.2 in lung cancer cell lines. Cancer Res 1996;56:5579-82
- Fong KM, Biesterveld EJ, Virmani A, Wistuba I, Sekido Y, Bader SA, Ahmadian M, Ong ST, Rassool FV, Zimmerman PV, Giaccone G, Gazdar AF, Minna JD. FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial le-sions and are associated with cancer-related FHIT cDNA splicing aberrations. Cancer Res 1997;57:2256-67
- Sozzi G, Tornielli S, Tagliabue E. Absence of Fhit protein in primary lung tumors and cell lines with FHIT gene abnormalities. Cancer Res 1997;57:5207-12
- Sard L, Accornero P, Tornielli S, Delia D, Bunone G, Campiglio M, Colombo MP, Gramegna M, Croce CM. The tumor-sup-pressor gene FHIT is involved in the regula-tion of apoptosis and in cell cycle control. Proc Natl Acad Sci USA 1999;96:8489-92
- Ji L, Fang B, Yen N, Fong K, Minna JD, Roth JA. Induction of apoptosis and inhi-bition of tumorigenicity and tumor growth by adenovirus vector-mediated fragile histi-dine triad (FHIT) gene overexpression. Can-cer Res 1999;59:3333-9
- Roz L, Gramegna M, Ishii H, Croce CM, Sozzi G. Restoration of fragile histidine triad (FHIT) expression induces apoptosis and suppresses tumorigenicity in lung and cer-vical cancer cell lines. Proc Natl Acad Sci USA 2002;99:3615-20
- Ishii H, Dumon KR, Vecchione A, Trapasso F, Mimori K, Alder H, Mori M, Sozzi G, Baffa R, Huebner K, Croce CM. Effect of adenoviral transduction of the fragile histi-dine triad gene into esophageal cancer cells. Cancer Res 2001;61:1578-84
- Dumon KR, Ishii H, Vecchione A, Trapasso F, Baldassarre G, Chakrani F, Druck T, Rosato EF, Williams NN, Baffa R, During MJ, Huebner K, Croce CM. Fragile histidine triad expression delays tumor development and induces apoptosis in human pancreatic cancer. Cancer Res 2001;61:4827-36
- Sevignani C, Calin GA, Cesari R, Sarti M, Ishii H, Yendamuri S, Vecchione A, Trapas-so F, Croce CM. Restoration of fragile histidine triad (FHIT) expression induces apoptosis and suppresses tumorigenicity in breast cancer cell lines. Cancer Res 2003;63:1183-7
- Askari MD, Vo-Dinh T. Implication of mito-chondrial involvement in apoptotic activity of fragile histidine triad gene: application of synchronous luminescence spectroscopy. Bio-polymers 2004;73:510-23