사상체질의학회지 (Journal of Sasang Constitutional Medicine)

  • 제16권3호
  • /
  • Pages.96-107
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  • 2004
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  • 1226-4075(pISSN)
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  • 2287-786X(eISSN)
사상체질의학회 (The Society Of Sasang Constitutional Medicine)
권호 표지

건율제조탕이 CCl4로 유발(誘發)된 간손상(肝損傷) 백서(白鼠)에 미치는 영향(影響)

The Effects of Gunyuljejo-tang on the CCl4-induced Liver Damage in Rat

  • 김정렬 (상지대학교 한의과대학 사상체질의학교실) ;
  • 김혁 (상지대학교 한의과대학 사상체질의학교실) ;
  • 양상묵 (상지대학교 한의과대학 사상체질의학교실) ;
  • 김달래 (상지대학교 한의과대학 사상체질의학교실) ;
  • 전종원 (상지영서대학 멀티미디어디자인학과)
  • Kim, Jung-Yul (Dept. of Sasang Constitutional Medicine, College of Oriental Medicine, SangJi Univ.) ;
  • Kim, Hyuk (Dept. of Sasang Constitutional Medicine, College of Oriental Medicine, SangJi Univ.) ;
  • Yang, Sang-Mook (Dept. of Sasang Constitutional Medicine, College of Oriental Medicine, SangJi Univ.) ;
  • Kim, Dal-Rae (Dept. of Sasang Constitutional Medicine, College of Oriental Medicine, SangJi Univ.) ;
  • Jeon, Jong-Weon (Dept. of MultiMedia Design, SangJi-YoungSeo College)
  • 투고 : 2004.10.28
  • 심사 : 2004.11.30
  • 발행 : 2004.12.31
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초록

1. Objectives This study was carried out to investigate the effects of Gunyuljejo-tang on the $CCl_4$-induced Liver Damage in Rats. 2. Methods Sprague-Dawley rats were devided into 5 experimental groups : Normal, $NS+CCl_4$(Solid extract of $CCl_4$ injection group after Normal Saline feed), $GYJJT+CCl_4$(Solid extract of $CCl_4$ injection group after Gunyuljejo-tang feed), $CCl_4+NS$(Normal Saline feed group after $CCl_4$ injection), $CCl_4+GYJJT$(Solid extract of Gunyuljejo-tang feed group after $CCl_4$ injection). Biochemical assays for serum enzyme activities such as AST, ALT, ALP, BUN, Creatinine, Uric Acid, Total Protein, Albumin, Total Cholesterol, Triglyceride, Glucose, and mRNA Revelation of Cytochrome p450 and activities such as LPO, GSH, GST, Glutathione Reductase, Glutathione Peroxidase, SOD, Catalase, Hydroxyproline, and ${\beta}$-Glucuronidase were performed. 3. Results (1) $GYJJT+CCl_4$ showed lower revelation of Cytochrome p450. (2) $GYJJT+CCl_4$ showed higher GSH activity than $NS+CCl_4$, $CCl_4+GYJJT$ showed higher GSH activity than $CCl_4+NS$ injection significantly. (3) $GYJJT+CCl_4$ showed higher GST activity than $NS+CCl_4$. $CCl_4+GYJJT$ showed higher GST activity than $CCl_4+NS$ significantly. (4) $GYJJT+CCl_4$ showed higher Glutathione Peroxidase activity than $NS+CCl_4$, $CCl_4+GYJJT$ showed higher Glutathione Peroxidase activity than $CCl_4+NS$ significantly. (5) $CCl_4+GYJJT$ showed higher SOD activity than $CCl_4+NS$ significantly. (6) $CCl_4+GYJJT$ showed higher Catalase activity than $CCl_4+NS$ significantly. (7) $GYJJT+CCl_4$ showed lower Hydroxyproline than $NS+CCl_4$ significantly, $CCl_4+GYJJT$ showed higher Hydroxyproline than $CCl_4+NS$ significantly. (8) $GYJJT+CCl_4$ showed higher ${\beta}$-Glucuronidase activity than $NS+CCl_4$, $CCl_4+GYJJT$ showed higher ${\beta}$-Glucuronidase activity than $CCl_4+NS$ significantly. 4. Conclusions Gunyuljejo-tang has the recovering effects on the $CCl_4$-induced Liver Damage significantly.

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