Journal of Biosystems Engineering

Korean Society for Agricultural Machinery (한국농업기계학회)
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Fabrication and Biomechanical Characteristics of Composite Ceramic Bone Scaffolds for Bone Tissue Engineering

골 생체조직공학을 위한 복합 세라믹 골 지지체의 제조와 생체역학적 특성

  • Kim E. S. (Dept. of Oral and Maxillofacial Surgery, Chungnam National University) ;
  • Chung J. H. (Dept. of Biosystem and Agricultural Engineering, Inst. og Ag. Sci. and Tech. Chonnam National University)
  • Published : 2004.10.01
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Abstract

Novel porous composite ceramic bone scaffolds composed of biodegradable PHBV(polyhydroxybutyrate-co-hydroxyvalerate) and TA(toothapatite) have been fabricated for bone tissue engineering by a modified solvent casting and particulate leach-ing method with salt-contained heat compression technique. The results of this study suggest that the PHBV-TA composite scaffold, especially the scaffold containing 30 weight$\%$ of TA may be a good candidate far bone tissue engineering of non-load bearing area in oral and maxillofacial region.

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References

  1. 유지, 이일우. 1998. 생체조직공학 - 개념과 응용 -. 고려의학. p. 109-152
  2. Crane, G., S. Ishaug and A. Mikos. 1995. Bone tissue engineering. Nat. Med. 1(12):1322-1324 https://doi.org/10.1038/nm1295-1322
  3. Vacanti C. and J. Vacanti. 1994. Bone and cartilage reconstruction with tissue engineering approaches. Otolaryngol Clin. N. Am. 27(1):263-276
  4. Lee, S. Y. 1996. Plastic bacteria: Progress and prospects of polyhydroxyalkanoate production in bacteria. Trends Biotechnol. 14:431-438 https://doi.org/10.1016/0167-7799(96)10061-5
  5. Pouton, C. W. and S. Akhtar. 1996. Biosynthesis polyhydroxyalkaonates and their potential in drug delivery. Adv. Drug Del. Rev. 18:133-162 https://doi.org/10.1016/0169-409X(95)00092-L
  6. Yamurlu M. F., F. Korusuz, I. Gursel, P. Korkusuz, Ors U and V. Hasirci. 1995. Sulbactam-cefoperazone polyhydroxybutyrate-co-hydroxyvalerate(PHBV) local antibiotic delivery system: In vivo effectiveness and biocompatibility in the treatment of implant-related experimental osteomyelitis. J Biomed. Mater. Res. 46:494-503 https://doi.org/10.1002/(SICI)1097-4636(19990915)46:4<494::AID-JBM7>3.0.CO;2-E
  7. Ten Cate, A. R. 1985. Oral Histology: Development, Structure, and Function, 2nd ed. New York, C.V. Mosby company. p. 130-135
  8. Choung, P. H. and E. S. Kim. 1997. Toothapatite as a bone substitute: An experimental study and clinical applications. J Kor. Dent. Ass. 35: 180-188
  9. Lee, J. H. and Y. M. Ju. 1999. Preparation of biodegradable polymer scaffold with uniform 3-dimensional porosity for tissue engineering. Korea patent application. No. 99-12325
  10. Joschek, S. B., R. Nies, R. Krotz and A. Gopferich. 2000. Chemical and physicochemical characteriazation of porous hydroxyapatite ceramics made of natural bone. Biomaterials 21:1645-1658 https://doi.org/10.1016/S0142-9612(00)00036-3

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