Journal of Haehwa Medicine (혜화의학회지)

Research Institute of Korean Medicine (대전대학교 한의학연구소)
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The Effect of Oenotherae Odoratae Semen on Hyperlipidemia

월견자(月見子)가 고지혈증(高脂血症)에 미치는 영향(影響)

  • Park, Ju-Hyun (Dept. of Neurophysiology, College of Oriental Medicine, Daejeon Univ.) ;
  • Namgoong, Uk (Dept. of Neurophysiology, College of Oriental Medicine, Daejeon Univ.) ;
  • Kim, Dong Hee (Dept. of Pathology, College of Oriental Medicine, Daejeon Univ.) ;
  • Park, Jong oh (Dept. of Pathology, College of Oriental Medicine, Daejeon Univ.)
  • 박주현 (대전대학교 한의과대학 신경생리학교실) ;
  • 남궁욱 (대전대학교 한의과대학 신경생리학교실) ;
  • 김동희 (대전대학교 한의과대학 병리학교실) ;
  • 박종오 (대전대학교 한의과대학 병리학교실)
  • Received : 2004.06.25
  • Published : 2004.06.30
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Abstract

As a long-term goal for the development of new prescriptions for hyperlipidemia, OBL was examined in the present study using a rat model in which the hyperlipidemia was induced. The major parameters related to lipid metabolism were investigated and the key findings are summarized below. 1. The body weight of hyperlipidemia-induced rats was increased by 50.6% compared to control group whereas the body weight of hyperlipidemia-induced rats with OBL injection showed 33.3% increases above the control group. 2. OBL-treated animals showed significant decreases in cholesterol levels compared to control group at the time point of 4 months after OBL injection. 3. OBL-treated animals showed significant decreases in T. cholesterol levels in comparison with the control group. 4. OBL-treated animals showed significant decreases in glucose levels compared to control group. 5. OBL-treated animal group showed decreases in SGOT and SGPT levels compared to control group, but its effects were not statistically significant. 6. Levels of HDL cholesterol were increased in OBL-treated animal group compared to the control, but the difference was statistically insignificant. 7. Levels of LDL cholesterol were decreased in OBL-treated animal group compared to the control group, but the difference was statistically insignificant.

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