Journal of Preventive Medicine and Public Health

The Korean Society for Preventive Medicine (대한예방의학회)
권호 표지

A seroepidemiological Study of Hepatitis B and C Virus (HBV and HCV) Infections in the Young Population in parts of Busan, Korea

일개 도시 일부 청년층(16-24세)의 B형, C형 간염에 관한 혈청역학적 연구

  • Ju, Young-Hee (Division of Cancer Control & Epidemiology, Research Institute, National Cancer Center) ;
  • Oh, Jin-Kyoung (Division of Cancer Control & Epidemiology, Research Institute, National Cancer Center) ;
  • Kim, Dong-Il (Department of Occupational Medicine, Sungkyunkwan University) ;
  • Lee, Duk-Hee (Department of Preventive Medicine, Kyungpook National University) ;
  • Kim, Byeong-Kweon (Department of Occupational and Environmental Medicine, Korea University) ;
  • Kim, Jung-Il (Department of Occupational Medicine, Dong-A University) ;
  • Jung, Kap-Yeol (Department of Occupational Medicine, Dong-A University) ;
  • Shin, Hai-Rim (Division of Cancer Control & Epidemiology, Research Institute, National Cancer Center)
  • 주영희 (국립암센터 연구소 암역학관리연구부) ;
  • 오진경 (국립암센터 연구소 암역학관리연구부) ;
  • 김동일 (성균관대학교 의과대학 산업의학교실) ;
  • 이덕희 (경북대학교 의과대학 예방의학교실) ;
  • 김병권 (고려대학교 의과대학 산업의학교실) ;
  • 김정일 (동아대학교 의과대학 산업의학교실) ;
  • 정갑열 (동아대학교 의과대학 산업의학교실) ;
  • 신해림 (국립암센터 연구소 암역학관리연구부)
  • Published : 2004.09.01
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Abstract

Objectives : To investigate the prevalence of hepatitis B and C virus infections and determine the associated risk factors among young adults in Busan, Korea, which is known to have a high incidence of liver cancer. Methods : The study population consisted of volunteer participants in a health survey during 2002, which included 1,350 students (515 males and 835 females) aged between 16 and 24 years, from three different schools in Busan. The participating students were asked to fill in a self-administered questionnaire which included lifestyle habits and risk factors of hepatitis. Sera obtained from the participants were studied for HBsAg, anti-HBs, and Anti-HCV by enzyme immunoassay (EIA) method and for liver function tests. Results : Among the study subjects (N=1,350), the seropositivities of HBsAg 7.9%(95% CI=7.8-8.0), 7.6%(95% CI=7.6-7.7) in male and 8.1%(95% CI=8.0-8.2) in female. And the seropositivity of Anti-HBs was 69.7%(95% CI=69.0-70.4), 70.5%(95% CI=69.8-71.2) in male and 69.2%(95% CI=68.5-69.9) in female. The seropositivity of Anti-HCV was 0.4%, 0.2% in male and 0.5% in female. The seropositivity for HBsAg in the subjects not having a hepatitis B vaccination history was twice(95% CI=1.0-4.4) that of those that did. Also, the seropositivity for HBsAg in subjects having experienced sexual intercourse was 1.7 times (95% CI=0.9-3.0) that of the subjects who had not. Conclusions : The present study confirmed the high prevalence of HBsAg seropositivity and sexual transmission of HBV among adolescents and young adults may occur. Further studies to evaluate the relationship between HBV vaccination and sexual transmission are required for the young population in Korea.

Keywords

References

  1. Kerea National Statistical office. Annnal Report on the came of Death Statistics; 2002
  2. MiristIy of Health and Welfare. Annual Report of the Korea Central Regisry; 2001
  3. Parkin DM, Whelan SL, Ferlay J, Teppo L, Thomas DB. Cancer Incidence in Five Continents Vol VIII. IARC; 2002. p.270-271
  4. Shin HR, AhnYO, Bae JM, Shin MH, Lee DH, Lee CW, Ohrr H, Ahn D, Ferlay J, Parkiin DM, Oh DK, Park JG. Cancer Incidence in Kcea Cancer Res Treat 2002; 34(6): 405-408
  5. IARC. WORLD CANCER REPORT; 2003. p.56-147
  6. WHO, UICC. Grobal Action Against Cancer,2003
  7. Chun BY, Lee MK, Rho YK. The Pervalerre of Hepatitis B Surface Antigen anmg Korean by Literature Review. Korean J Epidemiol 1992;14(1): 70-78 (Korean)
  8. Chung KW. Decrease of hepatitis B virus carrier rate in Korea. Korean J Internal Med 2000; 58(6): 605-607 (Korean)
  9. Jang MK, Lee JH, Kim YB, Kim HY, YooJY. The investigation for the change of HBsAg positive rate of grade ' junior high ' highschoolers for recent 3 years in Kangwon province. Korean J Internal Med 2000; 58(6): 608-615 (Kerean)
  10. Joo KR, Bang SJ, Song BC, Youn KH, Joo YH, Yang SH, Kim KR, ChungYH, Lee YS, Sub DJ. Hepatitis B Viral Markers of Korean Adults in the Late 1990s : Survey Data of 70,347 Health Screenees. Korean J Gastroenterol 1999; 33(5): 642-645 (Korean)
  11. Kim MS, Seo KS, Kim NJ, Choi SK, Sub SP, Choi JS,Kim SJ. A Study on the Positivities of Anti-HCV by Second-Generation ELISA in Rural area of Chounam Provine. Korean J Med 1997; 53(6): 741-746 (Kerean)
  12. Sherlock S. Disease of the liver and bilisry system, 9th ed. Lorden Bladcwell Sci Publi;1993. p.286
  13. Lee HS, Han CJ, Kim CY. Predominant etiologic association of hepatitis C virus with hepatocellular carcinoma compared with hepatitis B virus in elderly patients in a hepetris B-endemic area. Cancer 1993; 72(9): 2564-2567 https://doi.org/10.1002/1097-0142(19931101)72:9<2564::AID-CNCR2820720909>3.0.CO;2-#
  14. Harrison's Principles of lntanal Medicine. 15th ed. International ed. Vol 2. Acute viral Hepatitis (Chapter295).New York: McGrawHill Co.;2001.p.1729
  15. Kim CY. The Korean Society of Gastroenterology. Hepatitis. Korea; Kun-Ja Co.; 1998. p.37(Korean)
  16. Shin HR, Kim JY, lung KY, Kim WS, Hong YS, Kim BG, SR Kim, Lee BO, Park TS, Lee YH, Ok ID, Kim SR, Yang MK, Taniguchi M, Kim MM, Kim Kl. Prevalence of hepetris B and C virus infection among adults in Korea. HepudRes 1997;7:213-225
  17. Shin HR,Kim JY, Kim JI, Lee DH, Yoo KY, Lee DS, Franceschi S. Hepatitis B and C prevalence in a rural area of South Korea: the role of acupuncture.Br J cancer2003;87: 314-318
  18. Sohn SJ. A Study on the Positivity of HBsAg in Urban, Rural and Coastal Area. Korean J Prev Med 1986; 19(1): 45-55 (Korean)
  19. Yoo KY, Park BJ, Ahn YO. Sercepidemiology of Hepatitis B virus Infection in Healthy Korean Adults in Seoul. Korean J Prev Med 1988; 21(1): 89-98 (Korean)
  20. Lee SH, Cho CY, Meng KH. A Study on the Positive Rate of HBsAg and Anti-HBs and the Relationship between HBsAg Positive and Some Liver Function Tests among the Multiphasic Health Screening Examines. Korean J Epidemiol 1985;7(2): 265-273 (Kerean)
  21. Kim DS, Kim TS, Kim JY, Ahn Yo. A study on the Seropositivity of HBsAg among Biennial health Examinees; A nation-wide Muticenter Survey. Korean J Prev Med 2002;35(2): 129-135 (Kerean)
  22. Jung SH, Lee HS. Canse of Liver Cancer. J Korean Med Assoc 1992; 35: 8-13 (Korean)
  23. Kim IH, Kim OM, Lee CG. Hepatitis B examination and recognition change after 1 year in girl's high school students. J Korean Acad Fam Med 2001; 22(8): 1271- 1278(Korean)
  24. Shin NC, Bae ST, Kim SM, Oh SK, Yun DK, CHO KH, Hong MH, Lee CH. A survey of HBsAg and Anti-HBs positive young adults. J Korean Acad Med 1999; 20(6): 822-830 (Korean)
  25. Shin MS, Hwang TY, Kim CY. Serum HBsAg and Ahti-HBs Positive Rate among a city Health Center Visitors. Korean J Prev Med 1997;30(3): 508-517 (Korean)
  26. Arima S, Midritaka K, Horiike N, Kawai K, Matsubara H, Nakanifhi S, Abe M, Hasebe A, Tokumoto Y,Yamamoto K, Onji M.Change of acute hepatitis B transmission routes in Japan. Gastroenterol. 2003; 38(8): 772-775
  27. Margolis HS, Alter MJ, Hadler SC. Hepatitis B:evolving epideniology and implicatirns for control. Semin Liver Dis 1991;11(2): 84-92 https://doi.org/10.1055/s-2008-1040427
  28. Wilson BC,Moyer L, Schmid G, Mast E, Voigt R, Maloney F, Margolis H. Hepatitis B Vaccination in Sexually Transmitted Disease (STD) Clinics: A Survey of STD Programs. SexTransm Dis 2001;28: 148-152
  29. Han SW, Parle YU, Kim SM, Shin DH, Suh SP, Ryang DW, Kim SJ. A Study on Positive Rate of Anti-HCV in Korean Adults. Korean J Internal Med 1994; 47(6): 744-749 (Korean)
  30. Dubois F,Desenclos JC, Mariote N, Goudeao A. Hepatitis C in a French populetion-based survey, 1994: seroprevalence, frequency of viremia, genotype distribution, and risk factors. The Collaborative Study Group. Hepatology 1997;Jun25 (6):1490-1496
  31. Guadagnino V, Stroffolini T, Rapicetta M, Costaneo A, Kondili LA, Menniti-Ippolito F, Caroleo B, Costa C, Griffo G, Loiacono L, Pisani V, foca A, Piazza M. Prevalence, risk factors, and genotype distributirn of hepatitis C virus infection in the general population: a community-based survey in southern Italy. Hepatology 1997;26(4): 1006-1011 https://doi.org/10.1002/hep.510260431
  32. Dominguez A, Bruguera M, Vidal J, Plans P, Salleras L. Changes in the seroepidemiology of hepatitis B infection in Catalonia 1989-1996. Vaccine 2000;18(22):2345-2350 https://doi.org/10.1016/S0264-410X(00)00028-1
  33. Shin HR, Kim JY, Tomoyoshi Ohno, Kun Cao, M Mizokami, H Risch, SR Kim. Prevalence and risk factors of hepatitis C virus infection among Koreans in rural area of Korea. Hepatol Res 2000;17: 185-196 https://doi.org/10.1016/S1386-6346(99)00074-1
  34. Alter MJ, Kruszon-Moran D, Nainen OV, Mcquillan GM, Gao F, Moyer LA Kaslow RA, Margolis HS. The prevalence of hepatitis C virus infection in the united states. N Eng J Med 1999; 341(8): 556-562 https://doi.org/10.1056/NEJM199908193410802