Korean Journal of Clinical Laboratory Science (대한임상검사과학회지)

Korean Society for Clinical Laboratory Science (대한임상검사과학회)
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A Safety Experiment in Rats Exposed to BM-solution

BM-solution에 노출된 Rat의 안전성에 관한 조사

  • Kim, Dong Kyu (College of Veterinary Medicine, Chungbuk National University) ;
  • Kim, Kee Hyun (Biomist Technology Co., LTD.) ;
  • Lee, Nam Jin (College of Veterinary Medicine, Chungbuk National University) ;
  • Park, Jong Bae (Department of Biology and Institute of Traditional Medicine & Biosctence, Daejeon University) ;
  • Cho, Jung Hee (College of Veterinary Medicine, Chungbuk National University) ;
  • Kim, Yun Bae (College of Veterinary Medicine, Chungbuk National University) ;
  • Kang, Jong Koo (College of Veterinary Medicine, Chungbuk National University) ;
  • Kim, Young Kwon (Department of Clinical Laboratory Science, Gimcheon, College) ;
  • Hwang, Seock-Yeon (Department of Laboratory Medicine, Chungbuk National University)
  • 김동규 (충북대학교 수의과대학) ;
  • 김기현 (바이오미스트테크놀로지) ;
  • 이남진 (충북대학교 수의과대학) ;
  • 박종배 (대전대학교 생물학과 및 동서생명과학연구원) ;
  • 조정희 (충북대학교 수의과대학) ;
  • 김윤배 (충북대학교 수의과대학) ;
  • 강종구 (충북대학교 수의과대학) ;
  • 김영권 (김천대학 임상병리과) ;
  • 황석연 (충북대학교병원 진단검사의학과)
  • Published : 2004.12.31
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Abstract

This study was experiment on the safety of rat(Sprague-Dawley) exposed to natural herb oil(BM-solution). BM-solution was administered by inhalation to rats with the dose level of low(30 mg/8 min), middle(30 mg/4 min) and high(50 mg/4 min) in an airtight room for 4 weeks, respectively. Each groups, consisting of 5 rats, was examined for body weight changes, hematological analysis, serum biochemical analysis, organ weight, and histopathological findings, respectively. There were, dose-dependently, no changes of body weight and organ weights, no hematological anomalousness, and no other serum biochemical abnormality from the experiments. In addition, BM-solution was shown to have no specific toxicity by gross and histopathological findings. Therefore, it was concluded that BM-solution had no side effects on rats for 4 weeks.

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