Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
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Expression of mRANKL in rat PDL cell

Rat periodontal ligament cell에서의 RANKL mRNA의 발현

  • Kim, Hyun-Soo (Dept. of Periodontology, College of Dentistry and Dental Science Research Institute, Chonnam National University) ;
  • Chung, Hyun-Ju (Dept. of Periodontology, College of Dentistry and Dental Science Research Institute, Chonnam National University) ;
  • Kim, Young-Joon (Dept. of Periodontology, College of Dentistry and Dental Science Research Institute, Chonnam National University) ;
  • Kim, Ok-Su (Dept. of Periodontology, College of Dentistry and Dental Science Research Institute, Chonnam National University)
  • 김현수 (전남대학교 치과대학 치주과학교실 및 치의학연구소) ;
  • 정현주 (전남대학교 치과대학 치주과학교실 및 치의학연구소) ;
  • 김영준 (전남대학교 치과대학 치주과학교실 및 치의학연구소) ;
  • 김옥수 (전남대학교 치과대학 치주과학교실 및 치의학연구소)
  • Published : 2004.06.30
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Abstract

As the periodontal ligament cells show similar phenotype with osteoblasts, periodontal ligament cells are thought to play an important role in alveolar bone remodeling. According to recent studies, receptor activation of nuclear factor $^{\kappa}B$ ligand (RANKL) and osteoprotegerin (OPG) are expressed in periodontal ligament cells during tooth movement. Also periodontal ligament cells is known to play an important role in the progression of periodontal disease. This study was designed how the expression of RANKL and OPG in periodontal ligament cells was regulated by IL-1 ${\beta}in$ the concentration of $0.01{\sim}10$ ng/ml. The results are as follows; 1. Periodontal ligament cells which stimulated by 1L-1 ${\beta}$ increased soluble RANKL synthesis by dose-dependent pattern in the concentration of $0.01{\sim}10$ ng/ml. 2. 1L-1 ${\beta}$ induced mRANKL expression in dose-dependent manner in the concentration of $0.01{\sim}5$ ng/ml. 3. mOPG expression was not to be influenced by 1L-1 ${\beta}$. These results suggested that rat periodontal ligament cells could regulate osteoclastogenesis by stimulation of production of RANKL.

Keywords

References

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