거골에서 발생한 유윙 육종/원시신경 외배엽종양 - 1예 보고 -

Ewing's Sarcoma/PNET of the Talus - Report of a Case -

  • Kim, Sun-Young (Departments of Pathology, Dongkang General Hospital) ;
  • Kwon, Hyuck-Po (Departments of Diagnostic Radiology, Dongkang General Hospital) ;
  • Roh, Jae-Su (Departments of Orthopedics, Dongkang General Hospital) ;
  • Cho, Hyoun-Oh (Department of Orthopedics, Ulsan City General Hospital)
  • 발행 : 2004.11.30

초록

Ewing's sarcoma (ES)/PNET is common in both axial and appendicular skeletons, but is extremely rare in the talus. Here, we report a case of ES/PNET of the left talus in a 29-year-old male patient diagnosed by fine needle aspiration cytology, and review the literature on similar cases. The cytological smears were composed of individually dispersed small round cells and occasional clusters of loosely cohesive cells. The tumor cells were fragile, frequently exhibiting naked nuclei. Two distinct types of cells were observed. The light (chief) cells displayed round or slightly oval nuclei with frequent indentations, generally inconspicuous nucleoli, and a thin rim of cytoplasm, which sometimes harbored small vacuoles. The dark cells were smaller, displaying scanty cytoplasm with dense hyperchromatic nuclei, intermixed with chief cells, and often manifesting as small molded groups. However, no significant nuclear pleomorphisms or mitoses were noted. Tumor cells in the ceil block revealed positive cytoplasmic glycogen, as determined by a PAS stain with diastase control, and also exhibited positive immunoreactivity for CD99.

키워드

참고문헌

  1. Falk S, Alpert M. The clinical and roentgen aspects of Ewing's sarcoma. Am J Med Sci 1965;250:492-508 https://doi.org/10.1097/00000441-196511000-00002
  2. Kissane JM, Askin FB, Foulkes M, Stratton LB, Shirley SF. Ewing's sarcoma of bone: Clinicopathologic aspects of 303 cases from the intergroup Ewing's sarcoma study. Hum Pathol 1983;14:773-9 https://doi.org/10.1016/S0046-8177(83)80300-1
  3. Cohen J, Brown KA, Grice DS. Ewing's tumor of the talus(astragalus) simulating aseptic necrosis. J Bone Joint Surg Am 1953;35-A:1008-12
  4. Weissman SL, Salama R, Papo Y, Loewenthal M. Ewing's tumor of the talus misdiagnosed as avascular necrosis: A case report. J Bone Joint Surg Am 1966;48:333-6 https://doi.org/10.2106/00004623-196648020-00012
  5. Pandey S. Ewing's tumor of the talus: A case report. J Bone Joint Surg Am 1970;52:1672-3 https://doi.org/10.2106/00004623-197052080-00022
  6. Shirley Sk, Askin FB, Gilula LA, et al. Ewing's sarcoma in bones of the hands and feet: a clinicopathologic study and review of the literature. J Clin Oncol 1985;3:686-97 https://doi.org/10.1200/JCO.1985.3.5.686
  7. Maletz N, McMorrow LE, Greco A, Wloman SR. Ewing's sarcoma. Pathology, tissue culture, and cytogenetics. Cancer 1986;58:252-7 https://doi.org/10.1002/1097-0142(19860715)58:2<252::AID-CNCR2820580209>3.0.CO;2-9
  8. Adkins CD, Kitaok HB, Seidl RK, Pritchard DJ. Ewing's sarcoma of the foot. Clin Orthop 1997;343:173-82
  9. Serrano VJ, Caballero CO, Verdu RJ, et al. False postive with T1-201 in the study of Ewing's sarcoma of the astragalus caused by reflex sympathetic dystrophy. Rev Esp Med Nucl 1998;17:112-5
  10. Rasit AH, Sharaf I, Rahman HA. Ewing's sarcoma of the talus in a four-year-old child. med J Malaysia 2001; 56:86-8
  11. Renshaw AA, Perez-atayde AR, Fletcher JA, Granter SR. Cytology of typical and atypical Ewing's sarcoma/PNET. Am J Clin Pathol 1996;106:568-70 https://doi.org/10.1093/ajcp/106.5.568
  12. Kilpatrick SE, Renner JB, Creager A. Diagnostic Musculo-skeletal Surgical Pathology: Clinicoradiologic and Cytologic Correlations. Saunders: Elsevier, Inc (USA), 2004;37-43
  13. Cibas ES, Ducatman BS. Cytology: Diagnostic Principles and Clinical Correlates. In: Brown FM. Soft Tissue. 2nd ed. Saunders. 2003;441-5
  14. Orell SR, Sterrett GF, Walters MN, Whitaker D. Manual and Atlas of Fine Needle Aspiration Cytology. 3rd ed. Churchill Livingston:, Harcourt Brace and Co, 1999; 401-16
  15. Ewing J. Diffuse endothelioma of bone. Proc NY Pathol Soc 1921;21:17-24
  16. Leeson MC, Smith MJ. Ewing's sarcoma of the foot. Foot & Ankle 1989;10:147-51 https://doi.org/10.1177/107110078901000306