The Korean Journal of Cytopathology (대한세포병리학회지)

The Korean Society for Cytopathology (대한세포병리학회)
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Fine Needle Aspiration Cytology of Invasive Micropapillary Carcinoma of the Breast - Report of four Cases -

유방의 침윤성 미세유두모양 암종의 세침흡인 세포학적 소견 - 4예 보고 -

  • Kwon, Sun-Young (Department of Pathology, Keimyung University School of Medicine) ;
  • Jung, Hae-Ra (Department of Pathology, Keimyung University School of Medicine) ;
  • Kaug, Yu-Na (Department of Pathology, Keimyung University School of Medicine) ;
  • Kim, Sang-Pyo (Department of Pathology, Keimyung University School of Medicine) ;
  • Kwon, Kun-Young (Department of Pathology, Keimyung University School of Medicine) ;
  • Lee, Sang-Sook (Department of Pathology, Keimyung University School of Medicine)
  • 권선영 (계명대학교 의과대학 병리학교실) ;
  • 정혜라 (계명대학교 의과대학 병리학교실) ;
  • 강유나 (계명대학교 의과대학 병리학교실) ;
  • 김상표 (계명대학교 의과대학 병리학교실) ;
  • 권건영 (계명대학교 의과대학 병리학교실) ;
  • 이상숙 (계명대학교 의과대학 병리학교실)
  • Published : 2004.11.30
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Abstract

Invasive micropapillary carcinoma (IMPCa) is a rare variant of invasive ductal carcinoma of the breast. This variant is associated with a set of peculiar cytological findings and aggressive biological behaviors. In most reported cases, IMPCa has involved massive axillary lymph node metastases at the time of diagnosis. We experienced four cases of cytological features of IMPCa, all of which were verified by histological examination. Fine needle aspiration cytology (FNAC) revealed malignant epithelial cells, which formed small, oval to angulated papillary clusters, which lacked central fibrovascular cores. The histological findings of the four cases revealed both pure and mixed forms of IMPCa, composed of cohesive malignant epithelial cells, surrounded by distinctive clear spaces and separated by thin fibrous septa. All patients evidenced axillary lymph node metastases at the time of diagnosis. It is important to identify the peculiar cytological findings which would differentiate IMPCa from other diseases.

Keywords

References

  1. Siriaunkgul S, Tavassoli FA. Invasive micropapillary carcinoma of the breast. Mod Pathol 1993;6:660-2
  2. Paterakos M, Watkin WG, Edgerton SM, Moore I, Thor AD. Invasive micropapillary carcinoma of the breast. A prognostic study. Hum Pathol 1999;30:1459-63 https://doi.org/10.1016/S0046-8177(99)90168-5
  3. Luna-More S, Gonzalez B, Acedo C, Rodrigo I, Luna C. lnvasive micropapillary carcinoma of the breast. A new special type of invasive mammary carcinoma. Pathol Res Pract 1994;190:668-74 https://doi.org/10.1016/S0344-0338(11)80745-4
  4. Luna-More S, de los Santos F, Breton JJ, Canadas MA. Estrogen and progesterone receptors， c-erbB-2, p53, and bcl-2 in thirty-three invasive micropapillary breast carcinomas. Path Res Pract 1996;192:27-32 https://doi.org/10.1016/S0344-0338(96)80126-9
  5. Khurana K, Wilbur D, Dawson A. Fine needle aspiration cytology of the invasive micropapillary carcinoma of the breast. A report of two cases. Acta Cytol 1997;41:1394-8 https://doi.org/10.1159/000333547
  6. Wong S, Cheung H, Tse G. Fine needle aspiration cytology of invasive micropapillary carcinoma of the breast. A case report. Acta Cytol 2000;44:1085-9 https://doi.org/10.1159/000328603
  7. Kymarasinghe MP， Fernando MS, Sheriffdeen AH, Weerasekera K. Cytohistologic features of invasive micro-papillary carcinoma in a young female. Diagn Cytopathol 2000;23:196-8 https://doi.org/10.1002/1097-0339(200009)23:3<196::AID-DC11>3.0.CO;2-G
  8. Hatice B, Osman Z, Yildiz E, Metin C, Necmettin O. Fine-needle aspiration biopsy of invasive micropapillary carcinoma of the breast: a report of five cases. Diagn Cytopathol 2002;27:214-7 https://doi.org/10.1002/dc.10176
  9. Elston CW, Ellis IO. Pathological prognostic factors in breast cancer. The value of histological grade in breast cancer: experience from a large study with long-term follow-up Histopathology 1991;19:403-10
  10. Peterson JL. Breast carcinoma with an unexpected inside out growth pattern. rotation of polarization associated with angioinvasion. Path Res Pract 1993;189:780-3
  11. Pinder SE, Elston CW, Ellis IO. Invasive Carcinoma-Usual Histologic Types. In : Elston CW, Ellis IO, eds. The Breast. Systemic Pathology. 3rd ed. Edinburgh: Churchill Livingstone, 1998;322-4
  12. Hind N, Tracy W, Aleodor A, Jyotirmoy D, Volkan A, Daniel V. Clinicopathologic analysis of invasive micro-papillary differentiation in breast carcinoma. Mod Pathol 2001;14:836-41 https://doi.org/10.1038/modpathol.3880399
  13. 배영경, 김동석, 김미진, 이수정. 유방의 침윤성 미세유두 상 암종의 병리학적 특징. 대한병리학회지 1999;33:267-73