대한세포병리학회지 (The Korean Journal of Cytopathology)

대한세포병리학회 (The Korean Society for Cytopathology)
권호 표지

자궁경부 세포진에서 인유두종바이러스감염과 폐경후 편평세포 비정형성과의 연관성

Correlation Of Human Papillomavirus Infection and Postmenopausal Squamous Atypia in Cervical Cytology

  • 전이경 (성균관대학교 의과대학 삼성제일병원 병리과) ;
  • 문인걸 (성균관대학교 의과대학 내분비연구실) ;
  • 홍성란 (성균관대학교 의과대학 삼성제일병원 병리과) ;
  • 김혜선 (성균관대학교 의과대학 삼성제일병원 병리과) ;
  • 최종순 (성균관대학교 의과대학 삼성제일병원 병리과) ;
  • 박지영 (성균관대학교 의과대학 삼성제일병원 병리과) ;
  • 박종숙 (성균관대학교 의과대학 삼성제일병원 병리과) ;
  • 김태진 (성균관대학교 의과대학 산부인과) ;
  • 김희숙 (성균관대학교 의과대학 삼성제일병원 병리과)
  • Chun, Yi-Kyeong (Department of Pathology, Samsung Cheil Hospital, Sungkyunkwan University School of Medicine) ;
  • Moon, In-Gul (Department of Laboratory of Endocrinology, Samsung Cheil Hospital, Sungkyunkwan University School of Medicine) ;
  • Hong, Sung-Ran (Department of Pathology, Samsung Cheil Hospital, Sungkyunkwan University School of Medicine) ;
  • Kim, Hye-Sun (Department of Pathology, Samsung Cheil Hospital, Sungkyunkwan University School of Medicine) ;
  • Choi, Jong-Sun (Department of Pathology, Samsung Cheil Hospital, Sungkyunkwan University School of Medicine) ;
  • Park, Ji-Young (Department of Pathology, Samsung Cheil Hospital, Sungkyunkwan University School of Medicine) ;
  • Park, Jong-Sook (Department of Pathology, Samsung Cheil Hospital, Sungkyunkwan University School of Medicine) ;
  • Kim, Tae-Jin (Department of Obstetrics and Gynecology, Samsung Cheil Hospital, Sungkyunkwan University School of Medicine) ;
  • Kim, Hy-Sook (Department of Pathology, Samsung Cheil Hospital, Sungkyunkwan University School of Medicine)
  • 발행 : 2004.11.30
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초록

Postmenopausal squamous atypia (PSA) is a phenomenon characterized by cellular alterations mimicking condyloma in the uterine cervix of postmenopausal women. It is not associated with human papillomavirus (HPV) infection. The aim of this study is to correlate findings with HPV infection and the cytohistologic findings of PSA. Eighty-three smears from postmenopausal women, initially interpreted as ASCUS and low-grade squamous intraepithelial lesions(LSIL), were reviewed according to the criteria of PSA. Fifty-eight cases were subsequently reclassified as PSA. Forty cases categorized as PSA were available for HPV-DNA detection by a nested polymerase chain reaction. Eight of these 40 cases(20%) showed biopsy-proven LSIL lesions. The HPV-DNA was detected in 42.5%(17/40), compared to 25%(5/20) of control cases. The HPV-DNA detection rate of biopsy-proven LSIL was 62.5%(5/8). It has been concluded that cytologic differential diagnosis of PSA from LSIL is difficult due to because of poor histologic and viral correlation.

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참고문헌

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