Journal of the Korean Wood Science and Technology

The Korean Society of Wood Science & Technology (한국목재공학회)
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Chemical Constituents of Stationary Cultured Mycelia of Inonotus obliquus

Inonotus obliquus균의 정치배양이 균사체의 화학적 조성분에 미치는 영향

  • Shin, Yu-Soo (Research group of Forest Resources Science, Faculty of Agriculture, Hokkaido University) ;
  • Terazawa, Minoru (Research group of Forest Resources Science, Faculty of Agriculture, Hokkaido University) ;
  • Cho, Nam-Seok (School of Forest Resources, Chungbuk National University)
  • 신유수 (일본북해도대학 농학부 산림자원과학연구그룹) ;
  • 寺澤實 (일본북해도대학 농학부 산림자원과학연구그룹) ;
  • 조남석 (충북대학교 산림과학부)
  • Received : 2004.03.04
  • Accepted : 2004.05.20
  • Published : 2004.07.25
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Abstract

Seven compounds were isolated from stationary cultured mycelia of Inonotus obliquus, of which several of them showed certain antitumor activities. Seven compounds were identified as lanosterol(1), inotodiol(2), trametenolic acid(3), 3β,22,25-trihydroxy-lanosta-8-ene(6), 3β,22-dihydroxy-lanosta-8,24-diene(A), 3β-hydroxy- lanosta-8,24-dien-21-al(B) and methyl trametenolate(C), respectively. The precursor compound of sclerotium obtained from shaking-cultured and stationary-cultured mycelia of Inonotus obliquus is lanosterol. Ergosterol and ergosterol peroxide were obtained by shaking-culture, and the substituted compounds of C-21 and C-22 of lanosterol were obtained by stationary culture.

본 연구는 액체 정치배양한 Inonotus obliquus의 균사체 조성분을 분석하였으며, I. obliquus의 균핵과 진탕배양한 균사체의 성분조성을 비교하였다. I. obliquus 균의 정치배양 균사체가 생산하는 화학성분을 분석한 결과, 단리된 화합물은 lanosterol(1), inotodiol(2), trametenolic acid(3), 3β,22,25-trihydroxy-lanosta-8-ene(6), 3β,22-dihydroxy-lanosta-8,24-diene(A), 3β-hydroxy-lanosta-8,24-dien-21-al(B) 및 methyl trametenolate(C)이 확인되었다. 액체진탕배양 균사체가 생산하는 화합물과의 비교에 의해, 공통화합물은 lanosterol(1)이었고, ergosterol(7)과 ergosterol peroxide(8)는 액체진탕배양, lanosterol(1)의 C-21치환화합물과 C-22치환화합물은 정치배양함으로써 얻어짐을 알 수 있었다.

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