Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of Chilsun-Whan on Intestinal Mucosa and Gastrointestinal Transit Time in Rats

칠선환이 흰쥐 장점막과 위장관의 통과속도에 미치는 영향

  • Lee Chang Hyun (Department of Anatomy, College of Oriental Medicine, Woosuk University) ;
  • Han Woong (Department of Anatomy, College of Oriental Medicine, Woosuk University) ;
  • Kim Young Soo (Division of Biotechnology, Chonbuk National University) ;
  • Lee Kwang Gyu (Department of Oriental Pathology, College of Oriental Medicine, Woosuk University)
  • 이창현 (우석대학교 한의과대학 해부학교실) ;
  • 한웅 (우석대학교 한의과대학 해부학교실) ;
  • 김영수 (전북대학교 응용생물공학부) ;
  • 이광규 (우석대학교 한의과대학 한방병리학교실)
  • Published : 2004.02.01
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Abstract

Constipation is a common clinical problem that comprises of symptoms that include excessive straining, hard feces, feeling of incomplete evacuation and infrequent defecation. Although many conditions, such as metabolic problems, fiber deficiency, anorectal problem, an drug, can cause constipation. This study was examined the effects of Chilsun-Whan on intestinal mucosa and gastrointestinal transit time and plasma lipids in rats. Adult male rats were fed for weeks on diets containing no addition(basal diet group), 5% cellulose(cellulose group) and 2.5% . Chilsun-Whan group(Chilsun-Whan group). The results were as follows; 1. The fecal weght was significantly increased 2 times in Chilsun-Whan administrated group compare to basal diet group. 2. The gastrointestinal transit times was significantly decreased in Chilsun-Whan administrated group compare to basal diet. 3. Carmine red mixed with Chilsun-Whan, as a marker, was administered through a gastric tube for stomach or intracecally by a chronically implanted catheter for colon transit. Small intestinal transit and large intestinal transit time were significantly decreased in Chilsun-Whan administrated group compare to basal diet. 4. The height of jejunal villi was developed in Chilsun-Whan administrated group compare to basal diet The thickness of mucosa and muscle layer of colonic mucosa were significantly developed in Chilsun-Whan administrated group compare to basal diet group. 5. The change of goblet cell in colonic mucosa was increased acid mucin stained alcian blue in Chilsun-Whan administrated group compare to basal diet and cellulose group. 6. HDL-cholesterol of plasma lipid was increased in Chilsun-Whan administrated group compare to basal diet and cellulose groups. Theses results suggests that Chilsun-Whan may be used in prevention and treatment of constipation resulting in increase of fecal weight, decrease of gastrointestinal transit time. development of intestinal villi, intensify of stainability of acid mucin in colon.

Keywords

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