Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Inhibitory Effect of Water Extract of Adenophorae Radix on the Melanogenesis

소삼 물 추출물의 멜라닌 형성 억제 효과

  • Kang Hyun Sung (Department of Ophthalmology, Otolaryngology and Dermatology, College of Oriental Medicine, Wonkwang University) ;
  • Lim Nan Young (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Mun Yeun Ja (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lim Hong Jin (Department of Ophthalmology, Otolaryngology and Dermatology, College of Oriental Medicine, Wonkwang University) ;
  • Park Min Chul (Department of Ophthalmology, Otolaryngology and Dermatology, College of Oriental Medicine, Wonkwang University) ;
  • Lim Kyu Sang (Department of Ophthalmology, Otolaryngology and Dermatology, College of Oriental Medicine, Wonkwang University) ;
  • Kim Nam Kwen (Department of Ophthalmology, Otolaryngology and Dermatology, College of Oriental Medicine, Wonkwang University) ;
  • Woo Won Hong (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 강현성 (원광대학교 한의과대학 안이비인후피부과) ;
  • 임난영 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 문연자 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 임홍진 (원광대학교 한의과대학 안이비인후피부과) ;
  • 박민철 (원광대학교 한의과대학 안이비인후피부과) ;
  • 임규상 (원광대학교 한의과대학 안이비인후피부과) ;
  • 김남권 (원광대학교 한의과대학 안이비인후피부과) ;
  • 우원홍 (원광대학교 한의학전문대학원 한약자원개발학과)
  • Published : 2004.04.01
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Abstract

The aim of this study was to investigate the effect of Adenophorae Radix (AR) on melanogenesis of B16F10 mouse melanoma cells. The cells were treated for 5 days with AR at several concentrations. Treatment with AR suppressed melanin contents as a dose dependent manner without cytotoxicity and morphological change. And the extract of AR also inhibited tyrosinase activity, a key enzyme forming melanin, in a dose-dependent manner, Treatment of the cells with Adenophorae Radix also suppressed the increase of α-MSH (10 nM)-induced melanin contents and tyrosinase activity. These results suggest that AR inhibits melanogenesis and abrogates α-MSH-induced melanogenesis in B16 melanoma cells.

Keywords

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