Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Increasing Effect of Myricetin of Biotae Semen & Biotae Orientalis Folium on the Melanogenesis

백자인과 측백엽의 성분인 myricetin이 멜라닌 생성에 미치는 영향

  • Song Hwa Young (Department of Ophthalmology Otolaryngology and Dermatology, Wonkwang University) ;
  • Kim Jeong Keun (Department of Ophthalmology Otolaryngology and Dermatology, Wonkwang University) ;
  • Hong Seok Hoon (Department of Ophthalmology Otolaryngology and Dermatology, Wonkwang University) ;
  • Hwang Chung Yeon (Department of Ophthalmology Otolaryngology and Dermatology, Wonkwang University) ;
  • Kim Nam Kwen (Department of Ophthalmology Otolaryngology and Dermatology, Wonkwang University)
  • 송화영 (원광대학교 한의과대학 안이비인후피부과학교실) ;
  • 김정근 (원광대학교 한의과대학 안이비인후피부과학교실) ;
  • 홍석훈 (원광대학교 한의과대학 안이비인후피부과학교실) ;
  • 황충연 (원광대학교 한의과대학 안이비인후피부과학교실) ;
  • 김남권 (원광대학교 한의과대학 안이비인후피부과학교실)
  • Published : 2004.06.01
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Abstract

The unique biochemical pathways in melanocytes responsible for melanogenesis provide us with a rational mechanism-based means for developing both pharmacological regulators of pigmentation and cytotoxic chemotherapeutic drugs for melanoma, Myricetin is a polyphenolic antioxidant and a component from Biotae Semen, Biotae orientalis Folium. Therefore, the present study was conducted to evaluate the effects of myricetin on the melanogenesis in human melanoma (HM₃KO) cells. The cells were treated for 5 days with myricetin at several concentrations (10 - 100 μg/ml). Treatment with myricetin dose-dependently suppressed cell growth in HM₃KO cells, But melanin formation was markedly increased by myricetin as a dose dependent manner. Myricetin did not affect to tyrosinase activity, which is a key enzyme for melanogenesis, but significantly increased the level of tyrosinase protein expression, These results suggest that myricetin stimulate melanin synthesis of human melanoma cells through the modification of tyrosinase protein expression.

Keywords

References

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