Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effect of Cheonmabanhwa-Tang on the Changes in Cerebral Hemodynamics in Cerebral Ischemia of Rats

천마반하탕이 뇌허혈로 인한 뇌혈류역학적 변동에 미치는 영향

  • Yang Gi Ho (Department of Pathology, College of Oriental Medicine, Dongshin University) ;
  • Yun Young Dae (Department of Pathology, College of Oriental Medicine, Dongshin University) ;
  • Jeong Hyun Woo (Department of Pathology, College of Oriental Medicine, Dongshin University)
  • 양기호 (동신대학교 한의과대학 병리학교실) ;
  • 윤대영 (동신대학교 한의과대학 병리학교실) ;
  • 정현우 (동신대학교 한의과대학 병리학교실)
  • Published : 2004.06.01
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Abstract

Cheonmabanhwa- Tang (CBT) has been used in the Oriental Medicine for many centuries as a therapeutic agent for dizziness due to Poong-Dam, We reported that CBT had effects on the cerebral hemodynamics [regional cerebral blood flow (rCBF), pial arterial diameter (PAD), and mean arterial blood pressure (MABP)] in normal and cerebral ischemic rats. Therefor we designed to determine the mechanism of action of CBT. The changes of rCBF and MABP were determinated by laser-Doppler flowmetry(LDF), and the change of PAD was determinated by video-microscopy. The results were as follows: The CBT-induced increase in rCBF was significnatly inhibited by pretreatment with indomethacin (IDN, 1 ㎎/㎏, i.p.), an inhibitor of cyclooxygenase, or methylene blue (MTB, 10 ㎍/㎏, i.p.), an inhibitor of guanylate cyclase. The CBT-induced increase in PAD was also significantly inhibited by pretreatment with IDN or MTB. The CBT-induced increase in MABP was also significantly inhibited by pretreatment with IDN or MTB. In conclusion, it is suggested that CBT causes a diverse effect on cerebral hemodynamics via mediation of cyclooxygenase and guanylate cyclase.

Keywords

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