Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Inhibitory Action of Cortex Phellodendris on Nicotine-induced Behavioral Sensitization

황백의 니코틴의 활성 억제에 미치는 효과

  • Lee Bom Bi (Department of Oriental Medicine Science, Graduate School of East-West Medical Science, Kyung-Hee University) ;
  • Chae Yun Byung (Department of Oriental Medicine Science, Graduate School of East-West Medical Science, Kyung-Hee University) ;
  • Kwon Young Kyu (Department of Physiology, College of Oriental Medicine, Daegu Haany University) ;
  • Yang Cae Ha (Department of Physiology, College of Oriental Medicine, Daegu Haany University) ;
  • Kim Mi Ryo (Department of Physiology, College of Oriental Medicine, Daegu Haany University) ;
  • Kim Kwang Jung (Department of Physiology, College of Oriental Medicine, Daegu Haany University) ;
  • Hahm Dae Hyun (Department of Oriental Medicine Science, Graduate School of East-West Medical Science, Kyung-Hee University) ;
  • Lee Hye Jeong (Department of Oriental Medicine Science, Graduate School of East-West Medical Science, Kyung-Hee University) ;
  • Shim In Sub (Department of Oriental Medicine Science, Graduate School of East-West Medical Science, Kyung-Hee University)
  • 이봄비 (경희대학교 동서의학대학원 한의과학과 침구경락학전공) ;
  • 채윤병 (경희대학교 동서의학대학원 한의과학과 침구경락학전공) ;
  • 권영규 (대구한의대학교 한의과대학 생리학교실) ;
  • 양재하 (대구한의대학교 한의과대학 생리학교실) ;
  • 김미려 (대구한의대학교 한의과대학 생리학교실) ;
  • 김광중 (대구한의대학교 한의과대학 생리학교실) ;
  • 함대현 (경희대학교 동서의학대학원 한의과학과 침구경락학전공) ;
  • 이혜정 (경희대학교 동서의학대학원 한의과학과 침구경락학전공) ;
  • 심인섭 (경희대학교 동서의학대학원 한의과학과 침구경락학전공)
  • Published : 2004.06.01
Download PDF
⟨ Previous Next ⟩

Abstract

Substantial evidence suggests that repeated injections of nicotine produce increase in locomotor activity and expression of the immediate-early gene, c-fos in the dopaminergic target areas. Herbal medicine as a therapeutic intervention has been widely used for the treatment of mental dysfunction. Many studies have shown that Cortex Phellodendris (CP) can affect the biochemical balance in the central nervous system. In order to investigate whether CP have an influence on their nicotine-induced behavioral sensitization, we examined the effect of CP on nicotine-induced locomotor activity and c-Fos expression in the striatum and nucleus accumbens utilizing the Fos-like immunohistochemistry (FLI). Male SD rats received CP (200㎎/㎏, i.p.) 30 min before repeated daily injections of nicotine (0.4㎎/㎏, s.c.) for 7 days. Rats were followed withdrawal for 3 days and one challenge for 1 day. System challenge with nicotine produced a much larger increase in locomotor activity and accumbal FLI. Pretreatment with CP significanly inhibited nicotine-induced locomotor activity and FLI in the striuatum and nucleus accumbens. These results demonstrated that reduction in locomotor activity by CP may be reflected by reduction of dopamine release and postsynaptic neuronal activity in the striatum and nucleus accumbens. Our results suggest that CP may have therapeutic effect on nicotine addiction. Supported by a fund (99-PJ9-PG1-002-0004).

Keywords

References

  1. JAMA v.252 The role of the addictive process as a key step in causation of all tobacco-related disease. Pollin, W.
  2. Pop Dev Rev v.10 Addiction mortality in the United States: tobacco, alcohol and other substances. Ravenholt, R.T.
  3. Med Clin North Am v.76 Trends in cigarette smoking in the United States: the epidemiology of tobacco use. Fiore, M.D.
  4. N Engl J Med v.333 Nicotine medications for smoking cessation. Henningfield, J. E.
  5. N Engl J Med v.337 A comparison of sustained-release bupropion and placebo for smoking cessation. Hurt, R.D.;Sachs, D.P.;Glover, E.D.;Offord, K.P.;Johnston, J.A.;Dale, L.C.
  6. Science v.240 Nicotine likened to cocaine, heroin. Byrne, G.
  7. Nature v.382 Effect of nicotine on the nucleus accumbens and similarity to those of addictive drugs. Pontieri, F.E.;Tanda, G.;Chiara, DG.
  8. Brain Res Rev v.11 Enduring changes in brain and behavior produced by chronic amphetamine administration: a review and evaluation of animal model of amphetamine psychosis. Robinson, T.E.;Becker, T.B.
  9. Brain Res v.730 Nicotine injections into the ventral tegmental area increase locomotion and Fos-like immunoreactivity in the nucleus accumbens of the rats. Panagis, G.;Nisell, M.;Nomikos, G.G.;Chergui, K.;Svensson, T.H.
  10. Essays Neurochem. Neuropharmacol v.5 Stimulant-induced psychosis: an evaluation of animal methods. Segal, D.S.;Greyer, M.A.;Schuckit, M.A
  11. J Pharmacol Exp Ther v.246 Evidence that mesolimbic dopaminergic activation underlies the locomotor stimulant action of nicotine in rats. Clarke, P.B.S.;Fu, D.S.;Jakubovic, A.;Fibiger, H.C.
  12. Psychopharmacology v.107 The mesolimbic dopamine system is implicated in the reinforcing effects of nicotine. Corrigall, W.A.;Franklin, K.B.;Coen, K.M.;Clarke, P.B.
  13. J Neurosci Methods v.29 The use of c-fos as a metabolic marker in neuronal pathway tracing. Dragunow, M.;Faull, R.
  14. Science v.240 Expression of c-fos protein in brain: Metabolic mapping at the cellular level. Sagar, S.M.;Sharp, F.R.;Curran, T.
  15. Brain Res v.730 Nicotine injections into the ventral tegmental area increase locomotion and Fos-like immunoreactivity in the nucleus accumbens of the rats. Panagis, G.;Nisell, M.;Nomikos, G.G.;Chergui, K.;Svensson, T.H.
  16. Brain Res Mol Brain Res v.23 Nicotine induced c-fos expression in the striatum is mediated mostly by dopamine D1 receptor and is dependent on NMDA stimulation. Kiba, H.;Jayaraman, A.
  17. Synapse v.29 Inducivility of c-Fos protein in visuo-motor system and limbic structures after acute and repeated administration of nicotine in the rat. Mathieu-Kia, A.M.; Pages, C.;Besson, M.J.
  18. Behav Brain Res v.121 Nicotine-induced behavioral sensitization is associated with extracellular dopamine release and expression of c-Fos in the striatum and nucleus accumbens of the rat. Shim, I.;Javaid, J.I.;Wirtshafter, D.;Jang, S.Y.;Shin, K.H.;Lee, H.J.
  19. Pharmacol Biochem Behav v.46 Chronic nicotine treatment potentiates behavioral responses to dopaminergic drugs in rats. Suemaru, K.;Gomita, Y.;Furuno, K.;Araki, Y.
  20. Se Pu v.20 Preparative separation of alkaloids from Cortex Phellodendri by high speed countercurrent chromatography. Yuan, L.M.;Wu, P.;Xia, T.;Chen, X.X.
  21. Zhongguo Zhong Yao Za Zhi v.26 Effects of different processing products of Cortex Phellodendri on scavenging oxygen free radicals and anti-lipid peroxidation. Kong, L.D.;Yang, C.;Qui, X.I.;Wu, H.P.;Ye, D.J.
  22. J Ethnopharmacol v.73 Water extract of 1:1 mixture of Phellodendron cortex and Aralia cortex has inhibitory effects on oxidative stress in kidney of diabetic rats. Lee, Y.M.;Kim, H.;Hong, E.K.;Kang, B.H.;Kim, S.J.
  23. Yao Xue Xue Bao v.24 Determination of berberine and palmatine in cortex phellodendron and Chinese patent medicines by HPLC. Wang, Y.M.;Zhao, L.B.;Lin, S.L.;Dong, S.S.;An, D.K.
  24. The rat brain in stereotaxic coordinates. Paxinos, G.;Watson, C.
  25. Pharmacol Biochem Behav v.47 Tobacco abstinence, smoking cues, and the reinforcing value of smoking. Perkin, K.A.;Epstein, L.H.;Grobe, J.;Fonte, C.
  26. Br. J. Pharmacol. v.105 The effects of acute and repeated nicotine treatment on nucleus accumbens dopamine and locomotor activity. Benwell MEM;Balfour DJK.
  27. Brain Res v.537 Amphetamine behavioral sensitization and the excitatory amino acids. Karler, R.;Chaudhry, I.A.;Calder, L.D.;Turkanis, S.A.
  28. Schizophr Res v.33 Differential prevalence of cigarette smoking in patients with schizophrenic vs mood disorders Diwan, A.;Castine, M.;Pomerleau, C.S.;Meador-Woodruff, J.H.;Dalack, G.W.
  29. Ann N Y Acad Sci v.914 Studies of amphetamine or methamphetamine psychosis in Japan: relation of methamphetamine psychosis to schizophrenia. Yui, K.;Ikenoto, S.;Ishiguro, T.;Goto, K.
  30. Biol. Psychiatry v.46 Neurochemical brain imaging investigations of schizophrenia. Soares, J.C.;Innis, R.B.
  31. A role for sensitization in psychostimulants-induced paranoia and psychosis. Kaliva, P.W.;Rierce, P.C.;Sorg, B.A.
  32. FASEB J v.6 Dopaminergic mechanism in the pathogenesis of schizophrenia. Goldstein, M.;Deutch, A.Y.
  33. Br J Pharmaco v.99 Locomotor acitivity in rats after administration of nicotine agonists intracerebrally Reavill, C.;Stolerman, I.P.
  34. Br J Pharmacol v.94 Studies on the role of brain dopamine system in the psychostimulant response to nicotine. Vale, A.L.;Balfour, D.J.K.
  35. Brain Res Brain Res Rev v.25 A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants. Pierce, R. C.;Kalivas, P. W.
  36. Neuroscience v.50 On the significance of subterritories in the 'accumbens Zahm, D.S.;Borg, J.S.
  37. Neuroscience v.41 Specificity in the projection patterns of accumbal core and shell in the rat. Heimer, L.;Zahm, D.S.;Churchill, L.;Kalivas, P.W.;Wohltman, C.