Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Chongmyung-tang Inhibits the Cytotoxicity of Beta-amyloid in Neuro 2A Neuroblastoma Cells

베타 아밀로이드 유도성 Neuro 2A 세포독성에 대한 총명탕의 효과

  • Gug Yun Jai (Department of Neuropsychology, College of Oriental Medicine, Wonkwang University) ;
  • Choi Hyuk (Department of Neuropsychology, College of Oriental Medicine, Wonkwang University) ;
  • Kim Tae Heon (Department of Neuropsychology, College of Oriental Medicine, Wonkwang University) ;
  • Kang Hyung Won (Department of Neuropsychology, College of Oriental Medicine, Wonkwang University) ;
  • Lyu Young Su (Department of Neuropsychology, College of Oriental Medicine, Wonkwang University)
  • 국윤재 (원광대학교 한의과대학 신경정신과학교실) ;
  • 최혁 (원광대학교 한의과대학 신경정신과학교실) ;
  • 김태헌 (원광대학교 한의과대학 신경정신과학교실) ;
  • 강형원 (원광대학교 한의과대학 신경정신과학교실) ;
  • 유영수 (원광대학교 한의과대학 신경정신과학교실)
  • Published : 2004.10.01
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Abstract

The water extract of Chongmyung-tang has been traditionally used for treatment of memory-disorder in oriental medicine. This study was designed to investigate the protective mechanisms of Chongmyung-tang on β-amyloid or H₂O₂-induced cytotoxicity in Neuro 2A cells. The water extract of Chongmyung-tang significantly reduced both β-amyloid or H₂O₂-induced cell death and apoptotic characteristics through reduction of intracellular peroxide generation. Also, it inhibited the mitochondrial dysfunction including the disruption of mitochondria membrane permeability transition(MPT) and the modulation in expression of Bcl-2 family proteins in H₂O₂-treated H9c2 cells. Furthermore, pretreatment of quercetin inhibited the activation of caspase-3, in turn, degradation of ICAD/DFF45 were completely abolished in H₂O₂-treated cells. Taken together, that data suggest that the protective effects of the water extract of Chongmyung-tang against β-amyloid induced oxidative injuries may be achieved through modulation of mitochondrial dysfunction.

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