Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effect of Kangdangboeumbang on the Anti-diabetic Activity in NOD Mice

강당보음방이 자가면역 당뇨모델인 NOD mice의 혈당강하에 미치는 영향

  • Song Ho Cheol (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University) ;
  • Kim Sung Hoon (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University)
  • 송호철 (경희대학교 동서의학대학원 종양연구팀) ;
  • 김성훈 (경희대학교 동서의학대학원 종양연구팀)
  • Published : 2004.12.01
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Abstract

This study was aimed to verify the anti-diabetic activity of Kangdangboeumbang(KBB) in NOD mice which is Insulin Dependent Diabetes Mellitus(IDDM). The reduction of blood glucose after oral administration between 14 weeks by 2 weeks period to a NOD mice in KBB extract treatment group was showed from 7 day after comparing with control group. KBB extract treatment group increasd insulin secretion amount of serum than control group and decreased IFN­γ production. The pancreatic β-cells is destroyed by Th1-dependent autoimmune disease in NOD mice. KBB extract treatment group intercepted the progress of edematous islet controlling inflammatory mononuclear cells of infiltration that also destruction of pancreatic β-cells electively in a NOD mice.

Keywords

References

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