Biomedical Science Letters (대한의생명과학회지)
- Volume 10 Issue 4
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- Pages.397-401
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- 2004
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- 1738-3226(pISSN)
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- 2288-7415(eISSN)
Congenital Malformation Caused by Bisphenol A in Developing Chick Embryo
- Kim Su Won (Department of Biology, Keimyung University) ;
- Kim Jin Sik (Department of Biology, Keimyung University) ;
- Ryu Hye Myung (Department of Biology, Keimyung University) ;
- Nam Jin Sik (Department of Food & Nutrition, Suwon Women′s College) ;
- Cheigh Hong Sik (Department of Food Science and Nutrition, Pusan National University) ;
- Min Byung Tae (Vilac Company LTD. R&D Center) ;
- Park Soo Hyun (Vilac Company LTD. R&D Center) ;
- Yoo Min (Department of Biology, Keimyung University)
- Published : 2004.12.01
Abstract
We have examined congenital malformation in developing chick embryo caused by endocrine disruptor, bisphenol A (BPA). We injected BPA into the air sac of developing egg on day 4 of incubation. BPA-treated group with a concentration of 10 ㎍/egg showed a little decrease on their body length compared to the untreated group. But the group treated with 50㎍/egg revealed severe malformation in eyeballs and bills. The group treated with 100㎍/egg could not continue their development after few days of incubation. These results indicate that BPA clearly inhibits the normal development in chick and it should be toxic to the developing fetus at early stage and in various tissues. The study should contribute to the understanding of toxic effect of BPA in developing human fetus when exposed to the BPA.