대한한의학회지 (The Journal of Korean Medicine)
- 제25권3호
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- Pages.1-11
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- 2004
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- 1010-0695(pISSN)
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- 2288-3339(eISSN)
알코올로 유발된 생쥐의 위점막손상에 대한 사물탕의 보호효과
The Defensive Effect of Samooltang on Injury of Gastric Mucous Membrane of Mouse by Ethanol
- Lee Seong-Hwan (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
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Lim Seong-Woo
(Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University)
- 발행 : 2004.09.01
초록
Objectives : This study was carried out to investigate the effect of Samooltang (SMT) on the injury of gastric mucous membrane by ethanol in mice. Methods : The normal group was mice with no inflammation. The control group was mice with gastro-inflammation elicited by ethanol. The sample group was SMT-administered mice before gastro-inflammation elicitation. Results : In the immunohistochemical change, the distribution of SBA and COX-1 treated with SMT noticeably increased over the control group (p<0.05). The distribution of NF-κB P50, COX-2, and TUNEL treated with SMT noticeably decreased over the control group (p<0.05). The distribution of SMT was the same as the normal group. Conclusions : According to the above results, it is supposed that SMT would be helpful against gastritis and gastric ulcer caused by alcoholic drinks.