대한한의학회지 (The Journal of Korean Medicine)
- 제25권4호
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- Pages.161-170
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- 2004
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- 1010-0695(pISSN)
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- 2288-3339(eISSN)
Effects of Armillaria mellea Extract on Macrophage and NK Cell Activity
- Park Byoung-Wook (East-West Cancer Center, Daejeon University) ;
- Shin Jang-Woo (East-West Cancer Center, Daejeon University) ;
-
Cho Jung-Hyo
(East-West Cancer Center, Daejeon University) ;
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Son Chang-Gue
(East-West Cancer Center, Daejeon University) ;
-
Lee Yeon-Weol
(East-West Cancer Center, Daejeon University) ;
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Yoo Hwa-Seung
(East-West Cancer Center, Daejeon University) ;
- Lee Nam-Heon (East-West Cancer Center, Daejeon University) ;
- Yun Dam-Hee (East-West Cancer Center, Daejeon University) ;
-
Cho Chong-Kwan
(East-West Cancer Center, Daejeon University)
- 발행 : 2004.12.01
초록
Objective : The purpose of this study was to investigate the effects of Armillaria mellea extract (AME) on immune modulation focused on anti-cancer activity. Methods : To prove the effects of AME, we performed NO assay, NK cytotoxicity assay and RT-PCR of cytokine related with macrophage and NK cell activity. Results : AME increased NO production produced by macrophages in part. AME also enhanced the NK cell activities in destroying target cells (YAC-1 cells). AME up-regulated gene expression of IL-l, iNOS, TNF-a in RAW 264.7 cells and IL-l, IL-2, IFN-(equation omitted), TNF-a in splenocytes, respectively. Conclusion : From the above results, we assumed that AME is a potential drug for anti-cancer by activation of the macrophages and NK cells.