International Journal of Vascular Biomedical Engineering
- Volume 2 Issue 2
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- Pages.1-9
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- 2004
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- 1598-8929(pISSN)
Vascular Cell Responses against Oxidative Stress and its Application
- Ryoo, Sung-Woo (School of Medicine, Johns Hopkins University) ;
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Lee, Sang-Ki
(Department of Physiology, College of Medicine, Chungnam National University) ;
- Kim, Cuk-Seong (Department of Physiology, College of Medicine, Chungnam National University) ;
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Jeon, Byeong-Hwa
(Department of Physiology, College of Medicine, Chungnam National University)
- Published : 2004.10.30
Abstract
The history of studies in biology regarding reactive oxygen species (ROS) is approximately 40 years. During the initial 30 years, it appeared that these studies were mainly focused on the toxicity of ROS. However, recent studies have identified another action regarding oxidative signaling, other than toxicity of ROS. Basically, it is suggested that ROS are reactive, and degenerate to biomolecules such as DNA and proteins, leading to deterioration of cellular functions as an oxidative stress. On the other hand, recent studies have shown that ROS act as oxidative signaling in cells, resulting in various gene expressions. Recently ROS emerged as critical signaling molecules in cardiovascular research. Several studies over the past decade have shown that physiological effects of vasoactive factors are mediated by these reactive species and, conversely, that altered redox mechanisms are implicated in the occurrence of metabolic and cardiovascular diseases ROS is a collective term often used by scientist to include not only the oxygen radicals(
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