Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Effects of Cereal and Red Ginseng Flour on Blood Glucose and Lipid Level in Streptozotocin - Induced Diabetic Rats

곡물류와 홍삼분말 급여가 당뇨성 흰쥐의 혈당 및 지질대사에 미치는 영향

  • Shon, Mi-Yae (Dept. of Food and Nutrition, and Institute of Agriculture & Life Science, Gyeongsang National University) ;
  • Choi, Sun-Young (Dept. of Food and Nutrition, and Institute of Agriculture & Life Science, Gyeongsang National University) ;
  • Cho, Hyun-So (Dept. of Food and Nutrition, and Institute of Agriculture & Life Science, Gyeongsang National University) ;
  • Sung, Nak-Ju (Dept. of Food and Nutrition, and Institute of Agriculture & Life Science, Gyeongsang National University)
  • 손미예 (경상대학교 식품영양학과. 농업생명과학연구소) ;
  • 최선영 (경상대학교 식품영양학과. 농업생명과학연구소) ;
  • 조현소 (경상대학교 식품영양학과. 농업생명과학연구소) ;
  • 성낙주 (경상대학교 식품영양학과. 농업생명과학연구소)
  • Published : 2004.11.01
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Abstract

This study was conducted to examine the effects of feeding diets containing bioorganic power (BP) flour, wheat flour and rice flour on blood glucose and lipid level in streptozotocin-induced diabetic rats. BP flour was composed with the mixture of defatted flour (16 g soybean, 12 g wheat, 8 g barley), 2 g red ginseng and 2 g whole wheat flour per 100 g diet. Experimental groups were divided into non-diabetic normal and 4 diabetic groups containing control, 40% BP, 41.6% wheat and 41.6% rice flours with basal diet. BP group was significantly increased body weight gain and decreased plasma glucose compared with the diabetic control, wheat and rice flour groups (p<0.05). Food efficiency ratio of diabetic rats were significantly lower than that of the normal rats. The concentrations of total cholesterol and triglyceride in plasma and atherogenic index were significantly decreased in BP, wheat and rice diabetic groups than diabetic control (p<0.05). The concentration of total cholesterol and triglyceride in liver was significantly lower in BP group as compared with the diabetic control, wheat and rice flour groups (p<0.05). In conclusion, the results indicated that BP flour feeding improved plasma glucose level, total cholesterol and triglyceride in diabetic rats.

당뇨병 환자의 혈당조절 식이를 개발할 목적으로 탈지시킨 곡물류 분말(대두 40%, 밀가루 30%, 보리 20%)과 홍삼분말 5% 및 밀가루 5%로 혼합한 바이오활성(BP)분말을 전체식이의 중량비로 40% 투여가 streptozotocin으로 유발한 당뇨쥐의 혈당강하 효과와 체내지질의 농도에 미치는 영향을 조사하기 위하여 SD계 웅성 흰쥐를 정상대조군, 당뇨대조군, BP분말 식이 당뇨군, 밀가루 식이 당뇨군 및 쌀가루 식이 당뇨군으로 나누어 5주간 급여하여 식이실험을 행하였다. 식이효율은 당뇨 대조군에 비하여 모든 실험군에서 증가하였으며, BP 분말군은 당뇨대조군에 비하여 5주간 식이 섭취에 따른 체중증가(75.1 vs. 29.3 g)와 혈당강하(270.1 vs. 541.7㎎/dL) 효과가 각각 유의적으로 차이가 나타났다(p<0.05). 혈장 총콜레스테롤의 함량은 BP 분말군이 당뇨대조군에 비해 유의적으로 낮게 나타났으나(p<0.05), 다른 당뇨 식이군과는 차이가 없었다. 간에서 총콜레스테롤 및 중성지질의 함량은 BP 분말군이 정상대조군을 제외한 모든 당뇨 식이군에서 가장 낮은 수준을 나타내었다. 결론적으로 BP 분말을 흰쥐의 식이에 첨가하여 섭취시키면 혈당강하 효과와 체내 지질대사를 개선하는 효과를 나타내었다.

Keywords

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