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The Pharmaceutical Society of Korea (대한약학회)
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Suppressive Effects of Platycodon grandiflorum on the Progress of Carbon Tetrachloride-Induced Hepatic Fibrosis

  • Lee, Kyung-Jin (Department of Pharmacy, College of Pharmacy) ;
  • Kim, Ji-Young (Department of Pharmacy, College of Pharmacy, Research Center for Proteineous Materials Chosun University) ;
  • Jung, Kyung-Sik (Department of Pharmacy, College of Pharmacy, Research Center for Proteineous Materials Chosun University) ;
  • Choi, Chul-Yung (Division of Food Science, Chinju International University) ;
  • Chung, Young-Chul (Division of Food Science, Chinju International University) ;
  • Kim, Dong-Hee (Department of Pathology, College of Oriental Medicine, Daejeon University) ;
  • Jeong , Hye-Gwang (Department of Pharmacy, College of Pharmacy, Research Center for Proteineous Materials Chosun University)
  • Published : 2004.01.01
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Abstract

The suppressive effects of Platycodi Radix (Changkil: CK), the root of Platycodon grandiflorum A. DC (Campanulaceae), on the progress of acute carbon tetrachloride $(CCl_4)$-induced hepatic fibrosis were investigated in the rat. CK significantly suppressed $(CCl_4)$-induced hepatic necrosis and inflammation, as determined by the serum enzymatic activities of alanine and aspartate aminotransferase and serum tumor necrosis factor-${\alpha}$ levels, in dose-dependent manners. In addition, the increased hepatic fibrosis after acute $(CCl_4)$ treatment was suppressed by the administration of CK. CK also significantly prevented the elevation of hepatic ${\alpha}$ 1(I) procollagen (type I collagen) mRNA and ${\alpha}$ -smooth muscle actin (${\alpha}$ -SMA) expressions in the liver of $(CCl_4)$-intoxicated rats and also suppressed the induction of ${\alpha}$ -SMA and type I collagen in cultured hepatic stellate cells, in dose-dependent manners. These results suggest that the suppressive effects of CK against the progress of acute $(CCl_4)$-induced hepatic fibrosis possibly involve mechanisms related to its ability to block both hepatic inflammation and the activation of hepatic stellate cells.

Keywords

References

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