Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Acute Oral Toxicity and Pathogenicity of a Potential Probiotic Bacillus sp. A9184 Isolated from Soybean Paste

  • Lim, Jong-Hwan (College of Veterinary Medicine, Chungnam National University) ;
  • Park, Byung-Kwon (College of Veterinary Medicine, Chungnam National University) ;
  • Kim, Myoung-Seok (College of Veterinary Medicine, Chungnam National University) ;
  • Rhee, Man-Hee (College of Veterinary Medicine, Kyungpook National University) ;
  • Park, Seung-Chun (College of Veterinary Medicine, Kyungpook National University) ;
  • Yun, Hyo-In (College of Veterinary Medicine, Chungnam National University)
  • Published : 2004.09.01
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Abstract

This study provides more information about the potential toxicological risk of Bacillus sp. A9184 isolated from soybean paste. The evaluation was based on the guidelines of acute oral toxicity/pathogenicity for microbial pesticide and was to get more comprehensive understanding on the acute toxicity of the potential probiotic in Sprgue-Dawley rats. No dead animal was observed in rats after single oral administration with bacteria ($10^8$ CFU per animal). There were neither no treatment-related changes in clinical signs, nor changes in body weight and body temperature as com-pared with the untreated group. All tested animal showed the increase in body weight with time. The results obtained in this study suggest that the potential probiotic, Bacillus sp. A9184, is non-toxic for rat.

Keywords

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