Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
권호 표지

Thirteen-Week Repeated Oral Toxicity Study of Paecilomyces sinclairii in Sprague-Dawely Rats

랫드에서 매미눈꽃동충하초, Paecilomyces sinclairii의 13주 반복투여 독성에 관한 연구

  • 안미영 (농촌진흥청 농업과학기술원) ;
  • 지상덕 (농촌진흥청 농업과학기술원) ;
  • 김지영 (농촌진흥청 농업과학기술원) ;
  • 한재웅 (농촌진흥청 농업과학기술원) ;
  • 이용기 (농촌진흥청 농업과학기술원) ;
  • 이용우 (농촌진흥청 농업과학기술원) ;
  • 류강선 (농촌진흥청 농업과학기술원) ;
  • 이병무 (성균관대학교 약학대학) ;
  • 정나진 (성균관대학교 약학대학) ;
  • 김성남 (녹십자임상검사센타)
  • Published : 2004.09.01
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Abstract

Paecilomyces sinclairii was administered ad libitum feeding at percentage levels of 0, 1.25, 2.5, 5 and 10 percentage (calculated about 8 g/kg)/feeder for a period of 3 months. There was no observed clinical signs or deaths related to treatment in all groups tested. Therefore, the approximate lethal dose of P. sinclairii was considered to be higher than 8 g/kg in rats. Mild decreases in body weight gain were observed dose-dependently in P. sinclairii treated groups in dose response manner after 2 weeks. Interestingly, the weight of abdominal adipose tissues surrounding epididymides were greatly reduced by this Dongchunghacho, in parallel with the mild increase in body weight gain. However, the absolute weight change of other organs was not observed. There were not significantly different from the control group in urinalysis, ocular examination, hematological, serum biochemical value and histopathological examination. From these results, it is concluded that the no-observed-adverse-effect level (NOAEL) of P. sinclairii is less than 1.25% (1 g/kg) in rats in the present study.

Keywords

References

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