Journal of The Korean Society of Clinical Toxicology (대한임상독성학회지)

Korean society of Clincal Toxicology (대한임상독성학회)
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Arsenic Poisoning

비소 중독

  • Kim Yang Ho (Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine) ;
  • Lee Ji Ho (Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine) ;
  • Sim Chang Sun (Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine) ;
  • Jeong Kyoung Sook (Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine)
  • 김양호 (울산의대 산업 환경의학교실) ;
  • 이지호 (울산의대 산업 환경의학교실) ;
  • 심창선 (울산의대 산업 환경의학교실) ;
  • 정경숙 (울산의대 산업 환경의학교실)
  • Published : 2004.12.01
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Abstract

Arsenic poisoning has three types of poisoning. First, acute arsenic poisoning is usually caused by oral intake of large amount of arsenic compound with purpose of homicide or suicide. Second, chronic arsenic poisoning is caused by inhalation of arsenic in the occupational setting or by long-term oral intake of arsenic-contaminated well water. Third, arsine poisoning occurs acutely when impurities of arsenic in non-ferrous metal react with acid. Clinical manifestation of acute arsenic poisoning is mainly gastrointestinal symptoms and cardiovascular collapse. Those of chronic poisoning are skin disorder and cancer. Arsine poisoning shows massive intravascular hemolysis and hemoglobinuria with acute renal failure. Exposure evaluation is done by analysis of arsenic in urine, blood, hair and nail. Species analysis of arsenic is very important to evaluate inorganic arsenic acid and mono methyl arsenic acid (MMA) separated from dimethyl arsenic acid (DMA) and trimethyl arsenic acid (TMA) which originate from sea weed and sea food. Treatment with dimercaprol (BAL) is effective in acute arsenic poisoning only.

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