Journal of The Korean Society of Clinical Toxicology (대한임상독성학회지)
- Volume 2 Issue 1
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- Pages.15-19
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- 2004
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- 1738-1320(pISSN)
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- 2508-6332(eISSN)
Two Cases of Acute Renal Failure due to Rhabdomyolysis Complicating Doxylamine Succinate Intoxication
독시라민 과다복용에 의한 횡문근 용해 및 급성 신부전 2례
- Jung Jae Kwon (Department of Internal Medicine Daegu Fatima Hospital) ;
- Kim Sung Ho (Department of Internal Medicine Daegu Fatima Hospital) ;
- Kim In Seek (Department of Internal Medicine Daegu Fatima Hospital) ;
- Kim Seon Woong (Department of Internal Medicine Daegu Fatima Hospital) ;
- Ju Dong Wook (Department of Internal Medicine Daegu Fatima Hospital) ;
- Lee Duk Hyun (Department of Internal Medicine Daegu Fatima Hospital) ;
- Kim Jong Kun (Department of Internal Medicine, Emergency Medicine, Daegu Fatima Hospital)
- 정재권 (대구 파티마병원 내과) ;
- 김성호 (대구 파티마병원 내과) ;
- 김인식 (대구 파티마병원 내과) ;
- 김선웅 (대구 파티마병원 내과) ;
- 주동욱 (대구 파티마병원 내과) ;
- 이덕현 (대구 파티마병원 내과) ;
- 김종근 (대구 파티마병원 응급의학과학)
- Published : 2004.06.01
Abstract
Doxylamine succinate is an antihistamine used primarily as a sleep-induction. It can be gotten without a doctor's prescription in Korea, so it' s overdoses were frequently encountered. There were several reports that the overdoses of doxylamine might cause rhabdomyolysis, but few cases have been reported that it is related to acute renal failure (ARF). In cases that ARF occur, most of them are not severe enough to require hemodialysis. We experienced two cases of severe rhabdomyolysis complicating ARF after doxylamine overdose and treated with hemodialysis. Clinicians should be aware of the potentially lethal complications of rhabdomyolysis in patients who ingest doxylamine succinate and the needs for prompt intervention and careful assessment of renal function.