The Study to ETS Exposure and Their Biomarkers in Hair of Restaurant Workers

식당 종업원의 환경 담배 연기(ETS)의 노출과 머리카락 중 생체지표 연구

  • 조성준 (죤스 홉킨스대학교 보건대학원)
  • Published : 2004.06.01

Abstract

ETS (environmental tobacco smoke) is composed of exhaled mainstream smoke (MS) from the smoker, sidestream smoke (SS) emitted from the smoldering tobacco between puffs and contaminants that diffuse through the cigarette paper and mouth between puffs. These emissions contain both vapor phase and particulate contaminants. ETS is a complex mix of over 4,000 compounds. This mix contains many known or suspected human carcinogens and other toxic agents. More of these toxic compounds are found in SS than in MS. Workplace exposure to ETS can result in significant smoke intake, and passive smoke exposure may be related to impair respiratory function and an increase risk of lung cancer in nonsmokers. For nonsmokers sharing a work environment with cigarette smokers, the workplace must be considered hazardous independently of any specific industrial toxic exposure. The risk is particularly important when a high percentage of the workers smoke or where smokers and nonsmokers work in poorly ventilated areas. Nicotine is converted in the body to cotinine; cotinine therefore can be used as an indirect measure of a person's recent exposure to tobacco smoke. Levels of nicotine in hair and levels of cotinine in body fluids (saliva and urine) have been shown to increase with increasing environmental nicotine levels and with self-reported ETS exposure. The measurement of nicotine or cotinine in hair may be more appropriate for longer-term exposure to tobacco. The purpose of this study is to comparing airborne nicotine levels and hair cotinine level in restaurant workers. Concentration of airborne nicotine and hair nicotine (and cotinine) is closely related to exposed frequency of sidestream smoke in the workplace. Nicotine in hair is a better predictor of airborne nicotine than hair cotinine. Hair nicotine can be a useful tool to assess ETS exposure interventions. It may have limiting levels of ETS exposure by placing regulatory restrictions on smoking in workplaces and in public spaces.

Keywords

References

  1. 대한금연운동협의회. http://www.kash.or.kr/user/0_data_01.htm
  2. Al-Delaimy WK, Crane J and Woodward A. Passive smoking in children: Effect of avoidance strategies at home as measured by hair nicotine levels, Archives of Environ-mental Health 2001; 56(2): 117-122 https://doi.org/10.1080/00039890109604062
  3. Al-Delaimy, Crane J, Woodward A. Is the hair nicotine level a more accurate biomarker of environmental tobacco smoke exposure than urine cotinine?, J Epidemiol Community Health 2002; 56: 66-71 https://doi.org/10.1136/jech.56.1.66
  4. Benner CL, Bayona JM, Caka FM, Tang H, Lewis L, Crawford J, Lamb JD, Lee NL, Lewis EA, Hansen LD, and Eatough DJ. Environ. Sci. Technol 1989; 23: 688-699 https://doi.org/10.1021/es00064a007
  5. Benowitz NL. Cotinine as a biomarker of environmental tobacco smoke exposure, Epidemiol Rev 1996; 18(2): 43
  6. Caka FM, Eatough DJ, Lewis EA, Tang H, Hammond SK Leaderer BP, Koutrakis P, Spengler JD, Fasano A McCarthy J, Ogden MW and Lewtas J. Environ. Sci Technol 1990; 24: 1196-1203 https://doi.org/10.1021/es00078a007
  7. Centers for Disease Control and Prevention. State_ specific prevalence of cigarette smoking among adults, and children's and adolescent's exposure to environmental tobacco smoke-United States, 1996. MMWR 1997: 46(44); 1038-1043
  8. Covey et al. Cigarette smoking and occupational status: 1970 to 1990, Am. J. Public Health 1992; 82: 230
  9. Daisey JM, Mahanama KKR and Hodgson AT. Toxic Volatile Organic Compounds in Environmental Tobacco Smoke: Emission Factors for Modeling Exposures of California Populations; LBNL-36379; Lawrence Ber-keley National Laboratory: Berkeley, 1994
  10. Dimich-Ward et al. J Occup Environ Med 1997; 39(10): 946-948 https://doi.org/10.1097/00043764-199710000-00006
  11. Eatough DJ, Benner C, Mooney RL, Bartholomew D Steiner DS, Hansen LD, Lamb JD and Lewis EA. Pro-ceedings of the 79th Annual Meeting of the Air Pollution Control Association; Air Pollution Control Assoc.: Minneapolis 1986: 86-68
  12. Eatough DJ. In Modeling of Indoor Air Quality and Exposure; ASTM STP 1205; Nagda, N.L., Ed.; American Society for Testing and Materials: Philadelphia, 1993: 42-63
  13. Eatough DJ, Benner CL, Tang H, Landon B, Richards G, Caka FM, Crawford F, Lewis EA, Hansen LD and Eatough NL. Environment International 1989; 15: 19-28 https://doi.org/10.1016/0160-4120(89)90005-6
  14. Eatough DJ, Benner DL, Bayona JM, Richards G, Lamb JD, Lee ML, Lewis EA and Hansen LD. Environ. Sci. Technol 1989; 23: 679-687 https://doi.org/10.1021/es00064a006
  15. Eriksen MP, LeMaistre CA, Newell GR. Health hazard of passive smoking, Ann Rev Public Health 1988; 9: 47-70 https://doi.org/10.1146/annurev.pu.09.050188.000403
  16. Gayer N. Chemical Contaminants in Office Buildings, Am Ind Hyg Assoc J 1990; 51(12): 615-619 https://doi.org/10.1080/15298669091370248
  17. Guerin MR, Jenkins RA and Tomkins BA. The Chemistry of Environmental Tobacco Smoke Composition and Measurement, Chelsea, MI: Lewis Publishers, 1992
  18. Hammond SK, Leaderer BP, Roche AC and Schenker M. Atmospheric Environment 1987; 21: 457-462 https://doi.org/10.1016/0004-6981(87)90027-8
  19. Hammond SK. Exposure of U.S. Workers to Environmental Tobacco Smoke, Environmental Health Perspectives 1999; 107(2): 329-340
  20. Hepworth S. Senior Honors Thesis, Worcester, MA: Worcester Polytechnical Institute, 1987
  21. Jenkins RA, Moody RL, Higgins CE, Moneyhun JH. Nicotine in environmental tobacco smoke (ETS): comparison of mobile personal and stationary area sampling. Unpublished presentation at the proceedings of the EPA/AWMA Conference on Measurement of Toxic and Related Air Pollutants, Durham, North Carolina 1991
  22. Jordan TE. Vapor Pressure of Organic Compounds; Nes-cience Publisher: New York, 1954
  23. Joseph LaDou. Occupational & Environmental Medicine; A Simon & Schuster Co 1997, 2nd Edi., pp 718
  24. Kintz P, Ludes B and Mangin P. Evaluation of Nicotine and Cotinine in Human Hair, Journal of Forensic Sciences 1992; 37(1): 72-76
  25. LaKind JS, Ginevan ME, Naiman DQ et al. Distribution of exposure concentrations and dose for constituents of environmental tobacco smoke, Risk Analysis 1999; 19 (3):375-390
  26. Leaderer BP and Hammond SK. Environ. Sci. Technol 1991; 25: 770-777 https://doi.org/10.1021/es00016a023
  27. Lencka M, Szafranski A and Macynski A. Verified Vapor Pressure Data vol. 1: Organic Compounds Containing Nitrogen; PWN-Polish Scientific Publishers: Warszawa, 1984
  28. L$\"o$froth, G. Tobacco Control 1993: 2: 222-225 https://doi.org/10.1136/tc.2.3.222
  29. L$\"o$froth G, Burton RM, Forehanc L, Hammond SK, Sella RL, Zweldinger RB and Lewtas. J Environ Sci Technol 1989; 23: 610-614 https://doi.org/10.1021/es00063a015
  30. Lukachko AM et al. Environmental Tobacco Smoke: Health Risk or Health Hype? A Special Report. American council on science and health 1999
  31. Mannino DM, Siegel M, Rose D, Marshall RJ et al. Exposure to Environmental tobacco smoke exposure in the home and worksite and health effects in adults: results from the 1991 National Health Interview Survey. Tobacco Control 1997; 6(4): 296-305 https://doi.org/10.1136/tc.6.4.296
  32. Nafstad P, Jaakkola JJ, Hagen JA, Zahlsen K and Magnus P. Hair nicotine concentrations in mothers and children in relation to parental smoking, J Expo Anal Environ Epidemiol. 1997; 42: 272-279
  33. Nelson PR, Heavner DL, Collie BB, Maiolo KC and Ogden MW. Environ Sci Technol 1992; 26: 1909-1915 https://doi.org/10.1021/es00034a005
  34. Nelson PR, Ogden MW, Maiolo KC, Heavner DL and Collie BB. Indoor Air '90, Proceeding of the 5th International Conference on Indoor Air Quality and Climate 2; International Society for Indoor Air Quality: Toronto, 1990; 367-373
  35. Oldaker GB III and Conrad FW Jr. Result from measurements of nicotine in a tavern, In: EPA/AWWA International Symposium on Measurement of Toxic and Related Air Pollutants, Raleigh, North Carolina 1989 ; 577-582
  36. Peterson EL, Johnson CC and Ownby DR. Use of urinary cotinine and questionnaires in the evaluation of infant exposure to tobacco smoke in epidemiologic studies. J Clin Epidemiol 1997; 7: 917-923
  37. U.S. Department of Labor, Occupational Safety and Health Administration. 29 CFR Parts 1910, 1915, 1926, and 1928 Indoor Air Quality; Proposed Rule. 1994