Effect of Decreasing Body Weight with Plant Extracts Containing Rubi Fructus

복분자 함유 생약추출물의 체중 조절 효과에 관한 연구

  • Published : 2004.06.01

Abstract

Obesity is one of causes of the all adult diseases. We investigated the body weight decrease effect of the selected plants by digestive enzyme activity inhibition test. In a preliminary test, Inonotus obliquus and Rubus coreanus Miq. were found to be effective. Based on this result & previous result, we manufactured the mixture of plant extracts named as Misol$^{TM}$. Misol is applied anti-obesity beverage and rice. When we administered Miso/ sub TM/ to rats, it was found to be effective in body weight decrease. Result that is experimented during 20 weeks, is effective body weight and total cholesterol, triglyceride decrease. In case of human, anti-obesity beverage administered group showed 5.65% body weight decrease, 4% waist length decrease and 6% abdomen length decrease respectively. And anti-obesity rice administered group showed 2.3 kg body weight decrease, 2.9 cm waist length decrease and 3.74 cm abdomen length decrease respectively. This body control effect was supported by plant extracts in the Misol, anti-obesity beverage and rice - administered group. From these results, we suggest that this functional food could be helpful for body weight controlling obesity.

Keywords

References

  1. 김희선, 박영숙, 김창임 (1998): 구기자 섭취에 의한 고지방식이를 하는 흰쥐의 혈중 지질상태 변화, 한국영양학회지. 31, 263-270
  2. 대한당뇨병학회 (1992): 제31장 경구 혈당강하제, 당뇨병학, 고려의학, pp. 277-293
  3. 라정찬, 김정호, 이종은, 박형근, 김성훈, 강경선 (2003): 생약추출물을 이용한 키크는 쌀 개발에 관한 연구. 동의생리병리학회, 17, 815-818
  4. 성태수, 손규목, 배만종 (1994): 천궁의 열수 추출액이 고지방식이에 의한 흰쥐의 혈장, 간 및 지방조직의 지질함량과 분변 Steroids에 미치는 영향, 한국식품영양학회지. 7, 100-107
  5. 이미경, 이현수, 최근표, 오덕환, 김종대, 유창연, 이현용 (2003): 복분자 열매 추출물의 유용 생리활성 탐색. Korean J. Medicinal Crop Sci., 11, 5-12
  6. 이민숙, 김동명, 조병남, 구성자, 주상섭, 진동규, 이성희(2003): 누에고치 유래 실크 펩타이드와 녹차잎 및 식이 섬유소 보충이 체지방 및 혈청 지질 대사에 미치는 영향에 관한 연구. J. Korean Soc. Agric. Chem. Biotechnol., 46, 123-129
  7. 이숙희, 공규리, 정근옥, 박건영 (2003): 고지방식이를 섭취한 흰쥐에서 고추장의 체중 및 지방조직과 혈청내의 지질감소효과, 한국식품영양과학회지. 32, 882-886
  8. 한정순, 한용봉 (1994): 고지방식이 및 식이섬유가 흰주의 정소상체 지방조직의 지방세포에 미치는 영향. Kor. J. Nutr., 27, 118-126
  9. Abert, N. (1996): Insulin resistance and obesity: The role of fat distribution pattern. Diabetes Care, 19, 292-294 https://doi.org/10.2337/diacare.19.3.292
  10. Dan, B. and Andrew, G. (1993): Chinese herbal medicine. Material media. Eastland Press, Washington. p388
  11. Faust, I.M., Johnson, P.R., Stern, J.S. and Hirsch, J. (1978): Diet-induced adipovyte number increase in adult rats : a new model of obesity. Am. J. Physiol., 235, E279-286
  12. Ginberg, H.N., Le, N.A. and Gibson, J.C. (1985): Relation of the production and catabolism of plasma low density lipoprotein in hypertriglyceridemic subjects: Effect of weigh loss. J. Clin. Invest, 75, 614
  13. Grundy, S.M. Mok, H.V. and Zech, L. (1977): Transport of very low density lipoprotein triglyceride in varying degree of obesity and hypertriglyceridemia. J. Clin. Invest, 63, 1274
  14. Hirsch, J. and Han, P.W. (1969): Cellularity of rat adipose tissue : effects of growth, starvation and obesity. J. Lipid Research, 10, 77-82
  15. Hong, J.S., Kim, J.S., Kim, I.G., Kim, M.G. and Yun, S. (1995): Processing development of Bokbunja-wine. Annual Research Report of Minstry of Agricultural and Forestry, Report No. IA 1199512310103
  16. Hubert, H.B., Frinleib, M. and Mcnamara, P.M. (1983): Obesity as an independent risk for cardiovascular disease: A 26 year heart study. Circulation, 67, 968-977 https://doi.org/10.1161/01.CIR.67.5.968
  17. Hue, G.B. (1990): Pathology of obesity. Korean J. Nutr., 23, 333-336 https://doi.org/10.1079/BJN19690040
  18. Kahlos, K., Lesnau, A. and Lange, W. (1996): Preliminary tests of antiviral activity of two Inonotus obliquus strains. Fitoterapia, Vol. LXVII 4, 344-347
  19. Keirn, K. and Kies, C. (1979): Effects of dietary fiber on nutritional status of weaning mice. Cereal Chem., 56, 73-78
  20. Kim, H.C. and Lee, S.I. (1991): Comparison of the pharmacological effects of kinds of Rubi Fructus. J. Herbology, 6, 312
  21. Kim, S.Y. and Sook, Y.J. (1993): Effects of serum insulin, eating style and energy intake on the fatness. J. Korean Nutr., 26, 34-36
  22. Kim, T.J. (1997): Korean resources plants. Seoul University Republished, Seoul, p282
  23. Kissebah, A.H., Vydelingum, N., Murry, R" et al. (1982): Relation of body fat distribution to metabolic complication of obesity. J. Clin. Endocronol. Metab., 54, 254-260 https://doi.org/10.1210/jcem-54-2-254
  24. Krotkiewski, M., Bjorntorp, P., Sjostrom, L., et al. (1983): Impact of obesty on metabolism in men and women: Importance of adipose tissue metabolism. J. Clin. Invest., 72, 1150-1162 https://doi.org/10.1172/JCI111040
  25. Lemonnier, D. (1972): Effect of age, sex and site on the cellularity of the adipose tissue in mice and rats rendered obese by a high fat diet. J. Clin. Invest, 51, 2907-2915 https://doi.org/10.1172/JCI107115
  26. Muller, M.A., Cleary, M.P. and Kritchevsky, D. (1981): The effect of various types of dietary fiber on lipid storage in adipose tissue. Fed. Proc., 40, 853-859
  27. Peckhan, S.C., Entenman, C. and Carroll, H.W. (1962): The inluence of a hypercaloric diet on gross body and adipose tissue composition in the rat. J. Nutr., 77, 187-197
  28. Reiser, S. (1987): Metabolic effects of dietary pectins related to human. Health Food Technol., 91-99
  29. Vague, J. (1954): The degree of masculine differentiation of obesities: A factor determining prediposition ot diabetes, atherosclerosis, gout and uric-calculous disease. Am. J. Clin. Nutr., 4, 20-34
  30. Van Itallie, T.B. (1985): Health implications of overweight and obesity in the United State. Ann. Intern. Med., 103, 983-988